COLLEGE OF PHARMACY
 
 
 
FACULTY PROFILE
seporator

Thomas Wiese, Ph.D.
Associate Professor of Biochemistry
Xavier Associate Director, Louisiana Cancer Research Consortium

Telephone Number: 504-520-7433
Room Number: Qatar Pharmacy Pavilion- Room 412
Fax Number: 504-520-7950
Email Address: twiese@xula.edu

BIOGRAPHY

Dr. Wiese is an Associate Professor of Biochemistry in the Division of Basic Pharmaceutical Sciences in the College of Pharmacy at Xavier University of Louisiana.  He teaches molecular biology-biotechnology, medicinal chemistry and cancer biology lecture and laboratory courses while he also maintains an active research laboratory.  In 2007, Dr. Wiese was appointed  as the Xavier Associate Director of the Louisiana Cancer Research Consortium (LCRC) that includes Tulane and LSU Health Science Centers as well as Ochsner Clinic.  Dr. Wiese serves as manager of the Cell and Molecular Biology Core Facility in the Xavier RCMI cancer research program.  Dr. Wiese has also served as PI or manager of various collaborative,inter-university cancer research and education programs funded by the DoD and the NCI and now continues to build cancer research programs at Xavier within the LCRC and RCMI programs.

Dr. Wiese received a B.S. in Biology from the University of Michigan-Flint in 1984.  He then spent a few years doing analytical chemistry in an industrial lab before entering graduate school at Wayne State University School of Medicine in the Biochemistry Department.  As a graduate student, he developed a research project in the laboratory of Dr. Samuel Brooks that characterized the steroid ligand specificity of the estrogen receptor and complete his Ph.D. in 1995.  After spending one year teaching in the Chemistry Department of The University of Detroit-Mercy, Dr. Wiese moved to the toxicology program at The University of North Carolina at Chapel Hill to undertake postdoctoral studies with Drs. William Kelce and L. Earl Gray at the US EPA NHEERL where he developed projects addressing the molecular mechanisms of endocrine disrupting environmental chemicals.  In 1998, Dr Wiese accepted a State of Louisiana joint faculty position in both the Tulane School of Public Health and Tropical Medicine and the Xavier University of Louisiana College of Pharmacy where he has developed a research program addressing the cellular and molecular aspects of endocrine disruption in cancer promotion and progression.  In 2003, Dr. Wiese consolidated his research and academic efforts by moving fulltime to the Xavier University of Louisiana College of Pharmacy where he serves as research mentor for Xavier students from pharmacy, chemistry and biology.

The primary theme of research in the Wiese lab is the molecular mechanisms involved in nuclear receptor mediated endocrine disruption.  Projects underway include characterizations of gene, receptor and tissue specific effects of hormone active environmental chemicals and dietary supplements.  The goal of these studies is to define the endocrine disruption of these substances as primary molecular level events.  This information is then used to examine mechanisms of cancer promotion and progression as well as the characterization of hormone active contaminants with potential for novel endocrine activity.  This work involves cellular, molecular, biochemical and molecular modeling approaches applied to studies of estrogen, androgen and progestin activity.  Dr. Wiese has published papers involving endocrine disruption, structure-activity relationships of hormone active chemicals and estrogen mediated effects on gene induction and proliferation in breast cancer cells.

 

RESEARCH INTEREST

Projects in the Wiese Laboratory
The focus of research in the Wiese Lab is the study of xenobiotic chemicals acting as ligands for steroid hormone receptors.  Such inadvertent and unwanted “hormone” action can result in these receptors regulating genes at the wrong time and/or in the wrong tissue.  Such xenobiotics hormones are often called endocrine disrupting chemicals or EDCs.  The major human health concerns resulting from EDC activity are effects on fetal development and the promotion and/or progression of hormone regulated cancers.  In my lab, I develop and then employ in vitro biochemical, cellular and molecular biological assays for the identification and characterization of endocrine disrupting chemicals.  Computer modeling methods are then used to determine structure-activity relationships for these chemicals and to identify possible binding interactions with nuclear receptors.  Computer models are also used to make activity predictions of chemicals from environmental databases (virtual screening for endocrine disrupting chemicals).
The over all hypothesis examined in the lab is that some xenobiotic chemicals bind and regulate steroid hormone receptors inducing aberrant regulation of genes critical in development and/or related to cancer progression.

Most projects are directed at understanding what structure features of xenobiotics are related to their receptor action and then the identification of particular deleterious gene regulation events that result.  My lab is unique in that cell and molecular data we generate is modeled and then new predictions from modeling are evaluated with cell and molecular assays in the same lab.

The main focus of my endocrine disruption work has been pesticides, industrial chemicals and compounds from plants that are components of dietary supplements or activated soy (phytochemicals).  A particular interest is the different receptor mediated effects of the individual enantiomers of chiral xenobiotics.  Many industrial contaminants and pesticides are chiral with racemic mixtures ending up in the environment and/or in human exposure scenarios.  Since the metabolic process of individual environmental compartments and/or metabolism in humans often results in degradation or accumulation of only one enantiomer or the other, then understanding the toxic effects of each enantiomer is important.  We have found that in some cases, one enantiomer of a pesticide is estrogenic and the other is not.  In addition, we have found some cases where both enantiomers bind hormone receptors equally well, but each induces different receptor mediated responses.

Another interest is the phytochemicals (plant derived chemicals) that are in dietary supplements.  All such supplements are currently unregulated in the US.  Since many are thought to have estrogen activity, they are used to treat post-menopausal symptoms.  Working with analytical chemists at the USDA lab in New Orleans, we have identified estrogen, androgen and glucocorticoid activity in some components of some popular supplements and are now examining more specific gene regulation effects.
This type of regulation of steroid receptors is known in the pharmaceutical industry as selective receptor modulation and in the case of estrogens, drugs with such activity are specifically called selective estrogen receptor modulators (SERMs).  This selective concept is also applied to androgen and progesterone receptor active drugs (SARMs and SPARMs).  Considering that we have found this same type of activity in xenobiotics and phytochemicals, I feel that this is another way to characterize the relationship between drugs, environmental contaminants and herbal extracts.  All are foreign compounds to the body and so it makes sense that the properties and mechanisms would be similar.  This observation also highlights the potential for mechanistic toxicology research to assist in drug development and is yet another example of how natural products (herbals in dietary supplements) can be used as starting material to develop drugs.  I stress this linkage with the pharmacy students working in my lab so that they realize that the techniques they are learning are directly related to those used in the pharmaceutical industry.

My research involves collaborators at Xavier, Tulane, University of New Orleans and University of Toledo as well as scientists at US EPA laboratories.  Xavier students have been and are now involved in all aspects of my research.

The Lab Environment
The Wiese lab has “state of the art” facilities and equipment and is located near other well equipped labs in the College of Pharmacy. Dr. Wiese is actively involved with projects in the lab (he works in the lab!) and has daily interactions with research assistants and students.

The Lab Facilities
The Wiese laboratory consists of approximately 1000 square feet of space in the Xavier University college of Pharmacy (Qatar Pharmacy Pavilion  rms 409 and 411).  This lab is well equipped with instruments and equipment to address cell and molecular aspects of endocrine disruption research.  Specific capabilities include tissue culture, Real Time PCR, Proteomics, reporter assays and multifunction plate readers.  In addition, the Wiese lab has comprehensive computer hardware and software for molecular modeling studies (QSAR, Docking, virtual screening).

RCMI Cell and Molecular Biology Core Facility
Dr Wiese is manager of and his lab is host for the Xavier RCMI programs Cell and Molecular Biology Core facility.  This core has a staff of four research scientists that perform a wide range of cell and molecular as well as tissue culture and bioassay services for more than 25 faculty at Xavier and the greater New Orleans area.

Research Support
Thomas E. Wiese                                                                                             Fall, 2010

Active
59-6435-2-0021          (T. Wiese sub-Project PI)                    05/1/07 – 4/30/12                    1.2 calendar
USDA                         $95,094           “Defining the Hormone Activity of Plant Extracts and Dietary Supplements”, component of a USDA cooperative agreement with the Tulane-Xavier CBR.  This project examines the hormone activity of dietary supplements used to treat post-menopausal symptoms and provides bio assay support for the XU-CBR-USDA phytoestrogen projects.

LCRC Xavier Partnership       (Xavier Associate Director: Wiese)    7/1/07 –           20%
LCRC LA                                           $900,000/year
“Developing Cancer Disparities Research at Xavier”
This operating agreement expands the Louisiana Cancer Research Consortium (LCRC) to include Xavier University of Louisiana (as well as Tulane and LSU Health Science Centers).  As Manager of this effort, Dr. Wiese acts as the Xavier Associate Director of the LCRC leading the LCRC program at Xavier.  He chairs the Xavier LCRC Internal Advisory Board, is the Xavier Program Leader for the LCRC Signaling program, serves on the LCRC Leadership Team (with LCRC CEO and co-Directors) and serves on the LCRC Executive Committee.  Building on the cancer research programs developed at Xavier by the DOD Breast and Prostate Cancer training programs and the NCI P20 grant, this LCRC funding is focused on developing the infrastructure at Xavier to carry out cancer research.  Specific activities include: the recruitment of new cancer research faculty, building new and current cancer programs with seed and bridge grants, supporting a cancer programs office and maintaining a cancer research seminar and discussion group series at Xavier.  The overall goal of the LCRC is to build and expand the capacity of a core group of cancer researchers among multiple universities to eventually establish an NCI designated Louisiana Cancer Center.

N00014-06-1-1136     (T. Wiese sub-Project PI)                    9/1/09 – 9/30/10                      0.6 calendar
ONR                           $50,650           "Defining the Gene Induction and Methylation Profiles of Breast Cancer Cells Exposed to Aluminum Oxide/Carbon Nanotubes", component of the Tulane-Xavier CBR program project: “Biosensors for Defense Applications”.  This project has been changed to address the potential hormone activity of oil spill and dispersant residues.

1 G12 RR026260-01  (PI: D’Amour; Cell Mol Core Dir: Wiese)      7/1/09 – 6/30/14          2.4 calendar
NCRR RCMI 1                      $10,000,000
“Xavier's RCMI Cancer Research Program”
This grant establishes a comprehensive program to develop cancer research infrastructure and pilot projects at Xavier that will lead to long term, self sustaining cancer research programs for faculty.  My role is to direct the development and operation of the Cell and Molecular Core to support researchers at Xavier.

Tulane subcontract      (Xavier PI: Wiese)                  6/1/10 – 2/28/12                      1.2 calendar
Tulane-Waldemar Nelson and Co Inc            Contract         $45,000
“Central Wetlands Assimilation Pilot Demonstration of Wastewater and Biosolids Reuse for Orleans and St Bernard Parishes”
This subcontract addresses estrogen bioassays of samples in support of the demonstration biosolids reuse project between Tulane and Waldemar Nelson and Co Inc.

Pending

(PI: Stevens, coPI Wiese, Foroozesh)             Submitted April 2010                         20% in kind
DOD Breast Cancer HBCU/MSI Partnership                       
Successful completion of these specific aims will develop competitive and successful BC researchers at XU.  In addition, these researchers will develop the background and skills in pathway specific cancer biology approaches necessary to become independently funded BC researchers.  It is fully expected that a true partnership will develop between XU and Tulane Cancer Center through which lead compounds will be identified at XU and validated with TU mentoring.

Planned
To be submitted in 2010 or 2011
NIH NIEHS/NCI
This grant will focus on the aberrant gene regulation in cancer cells by the different enantiomer of chiral pesticides and environmental contaminants. 

To be submitted in 2010 or 2011
NIH NCAAM

This grant will focus on the hormone activity  and resulting gene regulation of dietary supplements used to treat post menopausal symptoms.

 

PUBLICATIONS, ABSTRACTS, PRESENTATIONS

Publications

1.    O'Keefe DH, Wiese TE, Brummet SR, Miller TW (1987) Uptake and metabolism of phenolic compounds by the water hyacinth (Eichhornia crassipes). In: Saunders JA, Kosak-Channing L, Conn EE (eds) Phytochemical Effects of Environmental Compounds. Plenum Publishing Corporation, New York, pp 101-129
2.    O'Keefe DH, Wiese TE, Benjamin MR (1987) Effects of monosubstituted phenols by the water hyacinth. In: Reddy KR, H. SW (eds) Aquatic Plants for Water Treatment and Resource Recovery. Magnolia Publishing Inc., pp 505-511
3.    Wiese TE, Kral LG, Dennis KE, Butler WB, Brooks SC (1992) Optimization of estrogen growth response in MCF-7 cells. In Vitro Cellular & Developmental Biology Vol. 28A, No. 9-10, pp. 595-602
4.    VanderKuur JA, Wiese T, Brooks SC (1993) Influence of estrogen structure on nuclear binding and progesterone receptor induction by the receptor complex. Biochemistry Vol. 32, No. 27, pp. 7002-7008
5.    Horwitz JP, Massova I, Wiese TE, Wozniak AJ, Corbett TH, Sebolt-Leopold JS, Capps DB, Leopold WR (1993) Comparative molecular field analysis of in vitro growth inhibition of L1210 and HCT-8 cells by some pyrazoloacridines. J  Med Chem Vol. 36, No. 23, pp. 3511-6
6.    Horwitz JP, Massova I, Wiese TE, Besler BH, Corbett TH (1994) Comparative molecular field analysis of the antitumor activity of 9H-thioxanthen-9-one derivatives against pancreatic ductal carcinoma 03 [published erratum appears in J Med Chem 1994 Sep 16;37(19):3196]. J Med Chem Vol. 37, No. 6, pp. 781-6
7.    Wiese TE, Brooks SC (1994) Molecular modeling of steroidal estrogens:  Novel conformations and their role in biological activity. J Steroid Biochem Mol Biol Vol. 50, No. 1-2, pp. 61-73
8.    Wiese TE, Dukes D, Brooks SC (1995) A molecular modeling analysis of diethylstilbestrol conformations and their similarity to estradiol-17beta. Steroids Vol. 60, No. 12, pp. 802-808
9.    Waller CL, Oprea TI, Chae K, Park H-K, Korach KS, Laws SC, Wiese TE, Kelce WR, Gray LE (1996) Ligand-based identification of environmental estrogens. Chem Res Toxicol Vol. 9, pp. 1240-1248
10.    Gray LE, Kelce WR, Wiese T, Tyl R, Gaido K, Cook J, Klinefelter G, Desaulniers D, Wilson E, Zacharewski T, Waller C, Foster P, Laskey J, Reel J, Giesy J, Laws S, McLachlan J, Breslin W, Cooper R, Di Giulio R, Johnson R, Purdy R, Mihaich E, Safe S, Sonnenschein C, Welshons W, Miller R, McMaster S, Colborn T (1997) Endocrine screening methods workshop report: Detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms. Reprod Toxicol Vol. 11, No. 5, pp. 719-750
11.    Wiese TE, Polin LA, Palomino E, Brooks SC (1997) Induction of the estrogen specific mitogenic response of MCF-7 cells by selected analogues of estradiol-17ß: A 3D QSAR study. J Med Chem Vol. 40, No. 22, pp. 3659-3669
12.    Bolger R, Nestich S, Wiese T, Ervin K, Checovich W (1998) Rapid screening of environmental chemicals for estrogen receptor binding capacity. Environ Health Perspect Vol. 106, No. 9, pp. 551-557
13.    Walker C, Ahmed SA, Brown T, Ho SM, Hodges L, Lucier G, Russo J, Weigel N, Weise T, Vandenbergh J (1999) Species, interindividual, and tissue specificity in endocrine signaling. Environmental Health Perspectives Vol. 107, pp. 619-624
14.    Burow ME, Boue SM, Collins-Burow BM, Melnik LI, Duong BN, Carter-Wientjes CH, Li SF, Wiese TE, Cleveland TE, McLachlan JA (2001) Phytochemical glyceollins, isolated from soy, mediate antihormonal effects through estrogen receptor alpha and beta. J Clin Endo Metab Vol. 86, No. 4, pp. 1750-1758
15.    Rubin VN, Ruenitz PC, Boyd JF, Boudinot D, Wiese TE (2002) Characterization of SERM activity in two triairylethylene oxybutyric acids. Biochemical Pharmacology Vol. 63, pp. 1517-1525
16.    Coleman KP, Toscano WA, Wiese TE (2003) QSAR Models of the in vitro Estrogen Activity of Bisphenol A Analogs. Quantitative Structure-Activity Relationships Vol. 22, pp. 78-88
17.    Boue SM, Wiese TE, Nehls S, Burow ME, Elliott S, Carter-Wientjes CH, Shih BY, McLachlan JA, Cleveland TE (2003) Evaluation of the estrogenic effects of legume extracts containing phytoestrogens. Journal of Agricultural & Food Chemistry Vol. 51, No. 8, pp. 2193-9
18.    Vu H, Ianosi-Irimie M, Danchuk S, Rabon E, Nogawa T, Kamano Y, Pettit GR, Wiese T, Puschett JB (2006) Resibufogenin corrects hypertension in a rat model of human preeclampsia. Experimental Biology & Medicine Vol. 231, No. 2, pp. 215-220
19.    Zhou CH, Nitschke AM, Xiong W, Zhang Q, Tang Y, Bloch M, Elliott S, Zhu Y, Bazzone L, Yu D, Weldon CB, Schiff R, McLachlan JA, Beckman BS, Wiese TE, Nephew KP, Shan B, Burow ME, Wang GD (2008) Proteomic analysis of tumor necrosis factor-alpha resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype - art. no. R105. Breast Cancer Research Vol. 10, No. 6, pp. R105
20.    Boue SM, Tilghman SL, Elliott S, Zimmerman MC, Williams KY, Payton-Stewart F, Miraflor AP, Howell MH, Shih BY, Carter-Wientjes CH, Segar C, Beckman BS, Wiese TE, Cleveland TE, McLachlan JA, Burow ME (2009) Identification of the Potent Phytoestrogen Glycinol in Elicited Soybean (Glycine max). Endocrinology Vol. 150, No. 5, pp. 2446-2453
21.    Rees BB, Figueroa YG, Wiese TE, Beckman BS, Schulte PM (2009) A novel hypoxia-response element in the lactate dehydrogenase-B gene of the killifish Fundulus heteroclitus. Comparative Biochemistry & Physiology Vol. Part A, Molecular & Integrative Physiology. 154, No. 1, pp. 70-77
22.    Zimmermann MC, Tilghman SL, Boue SM, Salvo VA, Elliott S, Williams KY, Skripnikova EV, Ashe H, Payton-Stewart F, Vanhoy-Rhodes L, Fonseca JP, Corbitt C, Collins-Burow BM, Howell MH, Lacey M, Shih BY, Carter-Wientjes C, Cleveland TE, McLachlan JA, Wiese TE, Beckman BS, Burow ME (2010) Glyceollin I, a Novel Antiestrogenic Phytoalexin Isolated from Activated Soy. Journal of Pharmacology & Experimental Therapeutics Vol. 332, No. 1, pp. 35-45
23.    Garrison AW, Guillette LJ, Wiese TE, Avants JK (2010) Persistent organochlorine pesticides and their metabolites in alligator livers from Lakes Apopka and Woodruff, Florida, USA. International Journal of Environmental Analytical Chemistry Vol. 90, No. 2, pp. 159-170
24.    Jiang QA, Payton-Stewart F, Elliott S, Driver J, Rhodes LV, Zhang QA, Zheng SL, Bhatnagar D, Boue SM, Collins-Burow BM, Sridhar J, Stevens C, McLachlan JA, Wiese TE, Burow ME, Wang GD (2010) Effects of 7-O Substitutions on Estrogenic and Anti-Estrogenic Activities of Daidzein Analogues in MCF-7 Breast Cancer Cells. Journal of Medicinal Chemistry Vol. 53, No. 16, pp. 6153-6163
25.    Payton-Stewart F, Khupse RS, Boue SM, Elliott S, Zimmermann MC, Skripnikova EV, Ashe H, Tilghman SL, Beckman BS, Cleveland TE, McLachlan JA, Bhatnagar D, Wiese TE, Erhardt P, Burow ME (2010) Glyceollin I enantiomers distinctly regulate ER-mediated gene expression. Steroids Vol. 75, No. 12, pp. 870-878
26.    Srisawat1 P, Streiffer AB, Barbeau DN, Wiese TE, Grimm D, Skaggs BK, Andrew J. Englande J, Reimers RS (2010) Reduction of estrogenic activity in wastewater following treatment with ferrate. Proceedings of the Water Environment Federation Vol. 2010,
27.    Boué SM, Burow ME, Wiese TE, Shih BY, Elliot S, Carter-Wientjes CH, McLachlan JA, Bhatnagar D (In Press) Phytoalexins from Red Kidney Bean (Phaseollus vulgaris L.) Enhance Estrogenic and Antiestrogenic Activities. Journal of Agricultural and Food Chemistry,
28.    Antoon JW, White MD, Meacham WD, Slaughter EM, Muir1 SE, Elliott S, Rhodes LV, Ashe HB, Wiese TE, Smith CD, Burow ME, Beckman BS (In Press) Anti-Estrogenic Effects of the Novel Sphingosine Kinase-2 Inhibitor ABC294640. Endocrinology,
Under Revision
1.    Antoon JW, Meacham WD, Slaughter EM, Rhodes LV, Ashe3 HB, Wiese TE, Burow ME, Beckman BS (Under Revision) Pharmacological Inhibition of Sphingosine Kinase Isoforms Alters Estrogen Receptor Signaling in Human Breast Cancer. Journal of Molecular Endocrinology,
2.    Lievers MJ, Pace KD, Wiese TE (Under Revision) Review of the Efficacy of Over the Counter (OTC) Herbal Supplements for Relieving Postmenopausal Symptoms.
3.    Schenck K, Rosenblum L, Wiese TE, Wymer L, Dugan N, Williams D, Mash H, Merriman B, Speth T (Under Revision) Removal and Transformation of Estrogens During the Coagulation Process.
Submitted
1.    Williams KYB, A MJ, E WT (Submitted) Quantitative Structure Activity Relationships of Phytoestrogens, Mycoestrogens, and Diethylstilbestrol Derivatives as Estrogens. QSAR and Combinatorlial Chemistry,
2.    Williams KYB, McLachlan JA, Wiese TE (Submitted) Conformational Searching of five Mycoestrogens and their similarity to 17beta-Estradiol and Diethylstilbestrol. Steroids,
In Preperation
1.    Wiese TE, Segar HC, Lang M, White AL, Li H, Bou SM (In Prep) Analysis of the In Vitro estrogen and androgen activity of dietary suppliments used to treat post menopausal symptoms.
2.    Wiese TE, Nehls S, Li H, Stevens CK, Garrison AW (In Prep) Enantiomer Selective Antiandrogen and Antiprogesterone Activity of Fipronil.
3.    Wiese TE, Nehls S, Coleman NA, Coleman KP (In Prep) The estrogen and antiandrogen activity of p-alkyl phenols in mammalian cells.
4.    Wiese TE, Nehls S, Lee JJ, Carter J (In Prep) The in vitro estrogen and androgen activity of bisphenol A analogues.
5.    Wiese TE, Nehls S, Carter J, Garrison AW (In Prep) The in vitro estrogen and antiandrogen activity of DDT analogues, isomers and enantiomers.
6.    Wiese TE, Nehls S, Hudson G, Lee JJ, Garrison AW (In Prep) Analogue, isomer and enantiomer specific in vitro hormone activity of cyclodiene pesticides.

Abstracts

1.    Wiese T, O'Keeffe DH (1985) Uptake of a variety of monosubstituted phenols by the water hyacinth. Metropolitan Detroit American Chemical Society Undergraduate Research Meeting, Ann Arbor, MI,
2.    Wiese TE, Lightbody JJ, Vinogradov SN (1988) Characterization of monoclonal antibodies to Eudistylia vancourverii chlorocruorin and their cross reactivities with Lumbricus terrestris. Poster #331, 72nd Annual Meeting of the Federation of American Societies for Experimental Biology, Las Vegas, NV, The FASEB Journal Vol. 2, No. 4, pp. A353
3.    Wiese TE, Palomino E, Horwitz JP, Brooks SC (1991) Comparative molecular field analysis (CoMFA) of the specific responses of MCF-7 cells to A-ring substituted estrogens. Poster MEDI-150, 201st meeting of the American Chemical Society, Atlanta, GA,
4.    VanderKuur JA, Wiese T, Near K, Brooks SC (1991) Influence of estrogen structure on nuclear binding, processing and gene induction by the receptor complex. Poster #957, 73rd Meeting of the Endocrine Society, Washington, DC,
5.    Brooks SC, Pilat MJ, Hafner M, VanderKurr J, Wiese T (1991) Differential induction of genes by structurally altered estrogens. Terra Symposia on Estrogens and Antiestrogens, New Paltz, NY,
6.    Horwitz JP, Massova I, Wiese TE, Bessler BH, Corbett TH (1993) Comparative molecular field analysis of the antitumor activity of 9H-thioxanthen-9-one derivatives against pancreatic ductal carcinoma 03. Third Drug Discovery and Development Symposium, San Diego, CA,
7.    Wiese TE, Horwitz JP, Brooks SC (1993) Optimizing the CoMFA variable of lattice step size. North Carolina Symposium on Molecular Modeling: Integration of Theory and Experiment, MCNC, Research Triangle Park, NC,
8.    Wiese TE, Polin LA, Palomino E, Horwitz JP, Brooks SC (1996) Induction of the estrogen specific mitogenic response in MCF-7 cells by selected analogues of estradiol-17ß: A 3D QSAR study. Poster #24, 25th National Medicinal Chemistry Symposium, Ann Arbor, MI,
9.    Lambright CR, Wiese TE, Kelce WR (1997) The active metabolite of methoxychlor binds human androgen receptor (AR) and inhibits AR-DNA binding and AR-induced transactivation. Poster #24, Triangle Conference on Reproductive Biology '97, University of North Carolina at Chapel Hill, NC,
10.    Wiese TE, Lambright C, Kelce W (1997) Lack of synergistic estrogen effects of dieldrin and endosulfan mixtures on MCF-7 and MVLN cells. Poster #1496, Society of Toxicology, 37th Annual Meeting, Seattle, WA, Fundamental and Applied Toxicology Vol. 36, No. 1, Part 2, "The Toxicologist", pp. 294
11.    Wiese TE, Lambright C, Kelce W (1997) Lack of synergistic estrogen effects of Dieldrin and endosulfan mixtures in mammalian cells. Poster #23, Estrogens in the Environment IV: Linking Fundimental Knowledge, Risk Assessment, and Public Policy, Arlington, VA,
12.    Wiese TE, Ostby JS, Kelce WR (1998) The estrogenic capacity of bisphenol analogues and metabolites in mammalian cell proliferation and reporter gene assays. Poster #486, Society of Toxicology, 37th Annual Meeting, Seattle, WA, Toxicological Sciences Vol. 42, No. 1-S, "The Toxicologist", pp. 98
13.    Kelce WR, Lambright CR, Wiese TE, Gray LE (1998) Antiandrogenic mechanism of methoxychlor. Poster #857, Society of Toxicology, 37th Annual Meeting, Seattle, WA, Toxicological Sciences Vol. 42, No. 1-S, "The Toxicologist", pp. 173
14.    Wiese TE, Waller CL (1998) CoMFA models of environmental chemicals that bind the estrogen or androgen receptors: Update, caveats and future directions. 8th International Workshop on Quantitative Structure-Activity Relationships (QSARS) in the Environmental Sciences, Baltimore, MD,
15.    Wiese TE (1998) The use of steroid hormone receptor crystal structures to characterize endocrine disrupting chemicals: What is the potential? 8th International Workshop on Quantitative Structure-Activity Relationships (QSARS) in the Environmental Sciences, Baltimore, MD,
16.    Wiese TE, Garrison AW (1999) The estrogen activity of o,p'-DDT and o,p'-DDD optical isomers is enantiomer specific. Endocrine Disruptors, Keystone Symposia, Tahoe City, CA,
17.    Bishop TC, Wiese TE (1999) Modeling the receptor-ligand interactions of environmental estrogens. Endocrine Disruptors, Keystone Symposia, Tahoe City, CA,
18.    Wiese TE, Garrison AW (1999) Enantiomer selective estrogen activity of o,p'-DDT and o,p'-DDD optical isomers. Society of Toxicology, 38th Annual Meeting, New Orleans, LA,
19.    Bishop TC, Wiese TE (1999) Molecular modeling simulations of receptor-ligand interactions for environmental estrogens. Society of Toxicology, 38th Annual Meeting, New Orleans, LA,
20.    Neely NS, Wiese TE (1999) Determinations of the in vitro estrogen activity of acetaminophen. 26th Annual MALTO Meeting, U. Tennessee College of Pharmacy, Memphis, TN,
21.    Bishop TC, Wiese TE (1999) Analysis of receptor-ligand interactions of environmental estrogens by molecular modeling. 26th Annual MALTO Meeting, U. Tennessee College of Pharmacy, Memphis, TN,
22.    Wiese TE, Nehls S (2000) Xenoestrogen Activity in Human and Trout Estrogen Receptor Reporter Assays: Species Specific Agonist and Antagonist Effects. Nuclear receptors 2000, Keystone Symposia, Steamboat Springs, CO,
23.    Miller-Schief L, Nehls S, Wiese TE (2000) Response element sequence determines xenoestrogen activation of estrogen regulated reporter genes. 27th Annual MALTO Meeting, Xavier University College of Pharmacy, New Orleans, LA,
24.    Miller-Schief L, Nehls S, Wiese TE (2000) Response element sequence determines xenoestrogen activation of estrogen regulated reporter genes. Gordon Research Conference on Environmental Endocrine Disruptors, Plymouth, NH,
25.    Nehls S, Wiese TE (2000) Xenoestrogen Activity in Human and Trout Estrogen Receptor Reporter Assays: Species Specific Agonist and Antagonist Effects. e.hormone 2000, New Orleans, LA,
26.    Miller-Schief L, Nehls S, Wiese TE (2000) Response element sequence determines xenoestrogen activation of estrogen regulated reporter genes. e.hormone 2000, New Orleans, LA,
27.    Boué SM, Wiese TE, Carter-Wientjes CH, Cleveland TE (2000) Estrogenic and Antiestrogenic Activities of Legumes and Other Plants Containing Phytoestrogens. e.hormone 2000, New Orleans, LA,
28.    Boué SM, Wiese TE, Carter-Wientjes CH, Cleveland TE (2000) Estrogenic and Antiestrogenic Activities of Legumes and Other Plants Containing Phytoestrogens. Joint Southeast-Southwest Regional Meeting of the American Chemical Society, New Orleans, LA,
29.    Schief L, Horwitz KB, Wiese TE (2001) Xenobiotic Regulation of the Progesterone Receptor in Breast Cancer Cells. e.hormone 2001, New Orleans, LA,
30.    Wiese TE, Nehls S (2001) Enantiomer Selective Estrogen and Antiandrogen Activity of Chiral Pesticides. Symposia on Chiral Pollutants: Enantioselectivity and Its Consequences, SETAC National Meeting,  Nov 10-15 2001, Baltimore, MD Vol. Invited Presentation,
31.    Wiese TE, Nehls S (2002) Ligand-Receptor Interaction Simulations to Predict Endocrine Disruptor Activity. 10th International Workshop on Quantitative Structure Activity Relationships (QSARs) in Environmental Sciences (QSAR 2002),  May 25-29 2002, Ottawa, ON, Canada,
32.    Coleman KP, Toscano WA, Wiese TE (2002) QSAR Models of the in vitro Estrogen Activity of Bisphenol A Analogs. 10th International Workshop on Quantitative Structure Activity Relationships (QSARs) in Environmental Sciences (QSAR 2002),  May 25-29 2002, Ottawa, ON, Canada,
33.    Wiese TE, Nehls S (2002) Modeling Simulations of the Ligand-Receptor Interactions of Environmental Chemicals Bound to the Estrogen Receptor. e.hormone 2002, New Orleans, LA,
34.    Thomas SL, Wiese TE, Nehls S (2002) An Investigation of the Endocrine Disrupting Potential of Organophosphate Pesticides. e.hormone 2002, New Orleans, LA,
35.    Boué SM, Wiese TE, Nehls S, Burow M, Elliot S, Carter-Wientjes CH, Shih BY, Cleveland TE (2002) Evaluation of the Estrogenic Effects of Legume Extracts Containing Phytoestrogens. e.hormone 2002, New Orleans, LA,
36.    Coleman KP, W. A. Toscano J, Wiese TE (2003) QSAR Models of the in vitro Estrogen Activity of Bisphenol A Analogs. Northland Chapter of the Society of Toxicology Spring Meeting,
37.    Coleman KP, Toscano WA, Jr., Wiese TE (2003) QSAR Models of the In Vitro Estrogen Activity of Bisphenol A Analogs Journal of the Minnesota Academy of Science Vol. 67, No. 1, pp. 23
38.    Garrison W, Jones J, Wiese T, Washington J, Jarman J, Avants J (2003) Observations of Enantioselectivity in the Fate, Persistence and Effects of Modern Pesticides. Dioxin 2003, the 23rd International Symposium on Halogenated Organic Pollutants and Persistent Organic Pollutants, August 24-29, 2003, Boston, MA,
39.    Boué SM, Burow ME, Wiese TE, Shih BY, Carter-Wientjes CH, Morales VS, Cleveland TE (2003) Antihormonal Effects of the Soybean Phytoalexin Glyceollin. E.Hormone 2003, New Orleans, LA,
40.    Lee N, Lang M, Li H, Boué SM, Wiese TE (2003) Evaluation of the Estrogen, Androgen and Glucocorticoid Activity of Dietary Supplements Commonly used to Treat Postmenopausal Symptoms. E.Hormone 2003, New Orleans, LA,
41.    Wiese TE, Nehls S, Li H, Stevens CK, Garrison AW (2003) Enantiomer Selective Hormone Activity of the Pesticide Fipronil: Antiandrogen and Antiprogesterone Activity. E.hormone 2003, New Orleans, LA,
42.    Wiese TE, Nehls S, Li H, Stevens CK, Garrison AW (2003) Enantiomer Selective Antiandrogen and Antiprogesterone Activity of Fipronil. Symposia on Chiral Chemistry: Catching Pollutants Right-handed, SETAC National Meeting,  Nov 8-13 2003, Auston, TX,
43.    Lang M, White A, Li H, Boué SM, Wiese TE (2004) The in vitro estrogen and androgen activity of the Lydia Pinkham herbal supplement. Festival of Scholars 2004, Xavier University of Louisiana,
44.    White AL, Wiese TE, Nehls S, Boue S (2004) The Influence of Alternative Herbal Menopause Treatments on the Proliferation of MCF-7 Breast Cancer Cells. E.Hormone 2004, New Orleans, LA,
45.    Lang M, Wiese TE, White A, Li H, Boué SM (2004) The in vitro Estrogen and Androgen Activity of the Lydia Pinkham Herbal Supplement. E.Hormone 2004, New Orleans, LA,
46.    White AL, Wiese TE, Nehls S, Boue S (2004) The Influence of Alternative Herbal Menopause Treatments on the Proliferation of MCF-7 Breast Cancer Cells. 2004 Annual Biomedical Research Conference for Minority Students (ABRCMS), November 10-13, Dallas, Texas,
47.    Lang M, Wiese TE, White A, Li H, Boué SM (2004) The in vitro estrogen and androgen activity of the Lydia Pinkham herbal supplement. 2004 Annual Biomedical Research Conference for Minority Students (ABRCMS), November 10-13, Dallas, Texas,
48.    Schenck KM, Speth TF, Parrett CJ, Merriman BW, Rosenblum L, Krishnan ER, Wiese TE (2004) Evaluation of the Removal of Ethynylestradiol by Granular Activated Carbon Treatment. SETAC National Meeting, Nov 14-18 2004. Portland, OR,
49.    Wiese TE, Li H, Nguyen HM, Hill SR (2005) INTERACTIONS OF ESTROGEN AND PROGESTIN ACTIVE ENVIRONMENTAL CHEMICALS ON BREAST CANCER CELL PROLIFERATION, SURVIVAL AND GENE EXPRESSION. Era of Hope 2005, June 8-11, 2005, Philadelphia, PA,
50.    Schenck K, Dugan N, Williams D, Merriman B, Rosenblum L, Krishnan R, Wiese T (2005) Evaluation of the Removal of Estrogens Through the Coagulation Process. SETAC National Meeting, Nov 13-17 2005. Baltimore, MD,
51.    Pace KD, Lievers MJ, Wiese TE (2007) Analysis of Scientific Publications for the Efficacy of Over the Counter (OTC) Herbal Supplements in Relieving Postmenopausal Symptoms. Festival of Scholars 2007, Xavier University of Louisiana,
52.    Segar HC, Lang M, White AL, Li H, Boué SM, Wiese TE (2007) Novel in vitro Estrogen and Androgen Activity of Dietary Supplements Commonly Used to Treat Postmenopausal Symptoms. The Endocrine Society's 89th Annual Meeting, June 1-5, 2007, Toronto, ON, CA,
53.    Williams KY, McLachlan JA, Wiese TE (2007) Quantitative Structure-Activity Relationship (QSAR) Models to Describe and Predict the Estrogen Receptor Binding Activity of Phytoestrogens, Mycoestrogens, and Stilbene Estrogens. The Endocrine Society's 89th Annual Meeting, June 1-5, 2007, Toronto, ON, CA,
54.    Segar HC, Skripnikova EV, Wiese TE (2008) The Application of SuperArray Focused PCR Arrays to the Study of Genes Regulated by Endocrine Disrupting Chemicals. e.hormone 2008, New Orleans, LA,
55.    Williams KYB, McLachlan JA, Wiese TE (2008) Conformational Searching, Flexibility, and Docking/Scoring to ER LBD of Five Mycoestrogens and their similarity to 17β-Estradiol and Diethylstilbestrol. e.hormone 2008, New Orleans, LA,
56.    Wiese T (2008) MOE in the Pharmacy Curriculum: Student Visualization and Identification of Drug Properties, Similarities and Mechanism of Action. 2008 User Group Meeting, Chemical Computing Group, Montreal, Quebec, CA,
57.    Wiese TE, Li H, Segar HC, Hill SR (2008) Interactions of estrogenic pesticides on breast cancer cell gene expression evaluated with a cancer focused PCR Array. Era of Hope 2008, June 25-28, 2008, Baltimore, MD,
58.    Iris Alao, Graham R, Haron S, Stevens CLK, Wiese T (2009) Cell Growth Inhibition Studies of Potential Tyrosine Kinase Tumor Growth Inhibitors. Spring 2009 National Meeting of the American Chemical Society, Salt Lake City, UT,
59.    Streiffer AB, Wiese T, Srisawat P, Grimm D (2009) Sample Preparation of Wastewater and Dissolved Solids for Use in an Estrogen Responsive Cellular Bioassay. Proceedings of the Water Environment Federation Vol. 2009, No. Session 47, pp. 3001-3014
60.    Antoon JW, White MD, Meacham WD, Slaughter EM, Muir SE, Elliott S, Rhodes LV, Ashe HB, Wiese TE, Smith CD, Burow ME, Beckman BS (2009) Sphingosine Kinase: A Novel Therapeutic Target for ER Signaling in Breast Cancer. e.hormone 2009, New Orleans, LA,
61.    Segar HC, Skripnikova EV, Li H, Wiese TE (2009) Interactions of Estrogenic Pesticides on Breast Cancer Cell Gene Expression Evaluated with a Cancer Focused PCR Array System. e.hormone 2009, New Orleans, LA,
62.    Streiffer AB, Wiese T, Srisawat P, Grimm D (2009) Sample Preparation of Wastewater and Dissolved Solids for Use in an Estrogen Responsive Cellular Bioassay. e.hormone 2009, New Orleans, LA,
63.    Tilghman SL, Bratton MR, Segar HC, Elizabeth Martin HI, McLachlan JA, Wiese T, Nephew K, Burow ME (2009) Endocrine Disruptor Regulation of miR-21 Expression in Breast Cancer Cells. e.hormone 2009, New Orleans, LA,
64.    Wiese TE, Segar HC, Skripnikova EV, Ashe H, Li H, Garrison AW (2009) Enantiomer selective gene regulation induced by chiral organochlorine pesticides in breast cancer cells. SETAC North America 30th Annual Meeting 11/19 - 11/23/2009 New Orleans, LA, Enantioselective Analysis of New and Emerging Chiral Chemicals,
65.    Srisawat P, Streiffer AB, Barbeau DN, Skaggs BK, Grimm D, Andrew J. Englande J, Reimers RS, Wiese TE (2009) Reduction of estrogenic activity in wastewater following treatment with ferrate. SETAC North America 30th Annual Meeting 11/19 - 11/23/2009 New Orleans, LA, EDCs and PPCPs in the environment,
66.    Streiffer A, Wiese TE, Srisawat P, Grimm D (2009) Novel Method for Preparation of Waste Water and Sludge Samples for Analysis in an Estrogen Responsive Cellular Bioassay. SETAC North America 30th Annual Meeting 11/19 - 11/23/2009 New Orleans, LA, Endocrine Disrupting Chemicals: Analytical methods and environment processes,
67.    Obih C, Wiese T (2010) Ligand-Receptor Binding Simulations of Xenobiotic Compounds. Festival of Scholars 2010, Xavier University of Louisiana,
68.    Wiese TE, Segar HC, Skripnikova EV, Ashe H, Li H, Garrison AW (2010) Enantiomer Selective Estrogen and Androgen Activity of Chiral Pesticides. 239th ACS National Meeting, San Francisco, CA, Third Agrochemical Symposium on Modern Chiral Pesticides: Enantioselectivity and its Consequences,
69.    Srisawat P, Reimers RS, Andrew J. Englande J, Wiese T, Barbeau D (2010) Reduction of Endocrine Disrupting Compounds (EDCs) in Municipal Wastewater by Ferrate (Iron VI) Oxidation. State of the Coast conference, Baton Rouge, LA, June 8, 2010,
70.    Srisawat1 P, Streiffer AB, Barbeau DN, Wiese TE, Grimm D, Skaggs BK, Andrew J. Englande J, Reimers RS (2010) Reduction of estrogenic activity in wastewater following treatment with ferrate. Proceedings of the Water Environment Federation, 83nd Annual Water Environment Federation Technical Exhibition and Conference WEFTEC 2010,

 

Invited Reviews, Abstracts and Seminars

1.    Wiese TE (1991) Computer aided molecular design at MCF. Compuscope: A News letter of Computer Resources at the Michigan Cancer Foundation Vol. 1, No. 2, pp. 1-3
2.    Wiese TE (1996) Characterization of ligand specific regulation of the estrogen receptor. Biology Department, The University of North Carolina at Pembroke, Pembroke, NC Vol. Seminar,
3.    Wiese TE, Waller CL (1996) Recent developments in the use of "in computero" techniques to identify endocrine disruptors. Platform Session #8, 17th Annual Meeting of the Society of Environmental Toxicology and Chemistry, Washington, DC Vol. Invited Presentation,
4.    Wiese TE, Kelce WR (1997) An introduction to environmental oestrogens. Chemistry & Industry Vol. 16, No. August 18, pp. 648-653 (see: http://ci.mond.org/9716/971610.html)
5.    Wiese TE (1997) Application of in vitro screening methods for the identification and characterization of environmental estrogens. Department of Toxicology, North Carolina State University, Raleigh, NC Vol. Seminar,
6.    Wiese TE (1998) Ligand structure as a predictor of endocrine disruptor potential. Gordon Research Conference on Environmental Sciences: Water, Henniker, NH Vol. Invited Presentation,
7.    Wiese TE (1998) Molecular Characterization of Environmental Estrogens. Department of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine Vol. Seminar,
8.    Wiese TE (1999) Molecular Characterization of Environmental Estrogens. Division of Basic Pharmaceutical Sciences, Xavier University College of Pharmacy Vol. Seminar,
9.    Wiese TE (1999) Molecular characterization of bisphenol and bisphenyl xenoestrogens. Workshop on Steroid Hormones and Brain Function, Breckenridge, CO Vol. Invited Presentation,
10.    Wiese TE, Garrison AW, Nehls S, Bishop TC (1999) Enantiomer selective in vitro hormone activity of o,p'-DDT and o,p'-methoxychlor optical isomers. Chiral Chemistry in the Environment, 218th meeting of the American Chemical Society, New Orleans, LA Vol. Invited Presentation,
11.    Wiese TE (2000) Examples of the Species Specific and Enantioselective Activity of Xenobiotic Estrogens. College of Pharmacy, The University of Tennessee at Memphis Vol. Seminar,
12.    Wiese TE (2000) Examples of the Species Specific and Enantioselective Activity of Xenobiotic Estrogens. Department of Biochemistry, Tulane University Medical Center Vol. Seminar,
13.    Wiese TE, Nehls S (2000) Virtual screening for endocrine disrupting chemicals: Examples, caveats and opportunities. Symposium on Computer-Aided Drug Discovery, Joint Southeast-Southwest Regional Meeting of the American Chemical Society, New Orleans, LA Vol. Invited Presentation,
14.    Wiese TE (2001) Examples of the Species Specific and Enantioselective Activity of Xenobiotic Estrogens. Department of Chemistry, The University of New Orleans Vol. Seminar,
15.    Wiese TE, Nehls S (2001) Enantiomer Selective Estrogen and Antiandrogen Activity of Chiral Pesticides. Symposia on Chiral Pollutants: Enantioselectivity and Its Consequences, SETAC National Meeting,  Nov 10-15 2001, Baltimore, MD Vol. Invited Presentation,
16.    Wiese TE (2001) Ligand-Receptor Modeling of EDCs. Sphinx Laboratories, Eli Lilly and Company, Research Triangle Park, NC Vol. Invited Presentation,
17.    Wiese TE (2001) Ligand-Receptor Modeling of EDCs. Office of Pesticides and Prevention, US EPA, Washington, DC Vol. Invited Presentation,
18.    Wiese TE (2001) Exploring the Enantiomer Selective Hormone Activity of Chiral Pesticides. National Exposure Research Laboratory, US EPA, Athens, GA Vol. Invited Presentation,
19.    Wiese TE (2002) Molecular Determinants of the Estrogen, Androgen and Progestin Activities of Environmental Hormones. e.hormone 2002, New Orleans, LA Vol. Invited Presentation,
20.    Wiese TE (2002) Exploring the Estrogen, Androgen and Progesterone Receptor Interactions of Endocrine Disrupting Chemicals. Department of Biological Sciences, Loyola University, New Orleans, LA Vol. Seminar,
21.    Wiese TE (2004) Exploring the Estrogen, Androgen and Progesterone Receptor Interactions of Endocrine Disrupting Chemicals. Natural Science Department, DeSales University, Center Valley, PA Vol. Seminar,
22.    Wiese TE (2005) Endocrine Disrupting Chemicals:
Mechanisms, Exposure and Detection
. Natural Science Department, DeSales University, Center Valley, PA Vol. Seminar,
23.    Wiese TE (2005) Analysis of the In Vitro estrogen and androgen activity of dietary supplements used to treat post menopausal symptoms. The Center for Drug Design and Development, The University of Toledo College of Pharmacy, Toledo, OH Vol. Seminar,
24.    Wiese TE (2007) Novel in vitro estrogen activity of pesticide mixtures, isomers and enantiomers. Breast and Ovarian Research Group, Louisiana Cancer Research Consortium,  Tulane Health Sciences Center Vol. Seminar,
25.    Wiese TE (2007) Nuclear receptor specificity of the isomers and enantiomers of typical endocrine disrupting pesticides. Environmental and Occupational Health Sciences Division, The University of Texas School of Public Health, Houston, Texas Vol. Seminar,
26.    Wiese TE (2007) Evaluating the activity of dietary supplements used to treat post menopausal symptoms. Department of Biological Sciences, The University of New Orleans, New Orleans, Louisiana Vol. Seminar,
27.    Wiese TE (2008) Structure and function of endocrine disrupting chemicals. Chemistry Club, Xavier University of Louisiana, New Orleans, Louisiana Vol. Seminar,
28.    Wiese TE (2008) in vitro assays to determine the estrogen activity of environmental samples: explanation, comparison and discussion. HDR Inc, Bellevue, WA Vol. Seminar,

 

 

 
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