Department of Chemistry

Xavier University of Louisiana

Tasha B. Toro, Ph.D.
Research Associate

Telephone Number: 504-520-5358
Room Number: NCF - Room 276
Email Address: ttoro@xula.edu
Courses

Genomics & Proteomics Lab (4150L)

Short Professional Biography
  • Postdoctoral Fellow          October 2008 – June 2013

            Sanford-Burnham Medical Research Institute, La Jolla, CA

  • Ph.D. in Molecular and Human Genetics             August 2002 - August 2008

            Baylor College of Medicine

  • B.S. in Biology     August 1998 -May 2002        

            Louisiana Scholars’ College, Northwestern State University

Research Interest

Dr. Toro’s research is focused on understanding the molecular basis for substrate specificity. Currently, she is working with Dr. Watt to understand how individual members of a family of enzymes known as lysine deacetylases (KDACs) select specific substrates from thousands of known cellular targets. Deacetylation is critical for proper regulation of many cellular processes and has been linked to numerous human diseases, such as cancer and inflammation.

  

Current Grant Support
Recent Publications

Toro TB, Painter RG, Haynes RA, Glotser EY, Bratton MR, Bryant JR, Nichols KA, Matthew-Onabanjo AN, Matthew AN, Bratcher DR, Perry CD, Watt TJ. Purification of metal-dependent lysine deacetylases with consistently high activity. Protein Exp. Purif. 2018 Jan 1;141:1-6. [PMID: 28843507]

Toro TB, Bryant JR, Watt TJ. Lysine deacetylases exhibit distinct changes in activity profiles due to fluorophore-conjugation of substrates. Biochemistry 2017 Aug 29;56(34):4549-4558. [PMID: 28749131]

Toro TB, Pingali S, Nguyen TP, Garrett DS, Dodson KA, Nichols KA, Haynes RA, Payton-Stewart F, Watt TJ. KDAC8 with high basal velocity is not activated by N-acetylthioureas. PLoS One. 2016 Jan 8;11(1):e0146900. [PMID: 26745872]

Toro TB, Watt TJ. KDAC8 substrate specificity quantified by a biologically relevant, label-free deacetylation assay. Protein Sci. 2015 Sep 24;24:2020-2032. [PMID: 26402585]

Toro TB, Nguyen TP, Watt TJ. An improved 96-well turbidity assay for T4 lysozyme activity. MethodsX. 2015 May 18;2:256-62. [PMID: 26150996]

Toro TB, Toth JI, Petroski MD. The cyclomodulin CIF alters cullin neddylation dynamics. J Biol Chem. 2013 May 24;288(21):14716-26. [PMID:23589306]

Lyumkis D, Doamekpor SK, Bengtson MH, Lee JW, Toro TB, Petroski MD, Lima CD, Potter CS, Carragher B, Joazeiro CA. Single-particle EM reveals extensive conformational variability of the Ltn1 E3 ligase. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1702-7. [PMID:23319619]

Paschini M, Toro TB, Lubin JW, Braunstein-Ballew B, Morris DK, Lundblad V.  A naturally thermolabile activity compromises genetic analysis of telomere function in Saccharomyces cerevisiae. Genetics. 2012 May;191(1):79-93. [PMID:22377634]

Gao H, Toro TB, Paschini M, Braunstein-Ballew B, Cervantes RB, Lundblad V.  Telomerase recruitment in Saccharomyces cerevisiae is not dependent on Tel1-mediated phosphorylation of Cdc13.  Genetics. 2010 Dec;186(4):1147-59. [PMID: 20837994

Department of Chemistry

504-520-5082