Chew GH, Galloway LC, McIntyre NR, Schroder LA, Richards KM, Miller SA, Wright DW, Merkler DJ. Ubiquitin and ubiquitin-derived peptides as substrates for peptidylglycine alpha-amidating monooxygenase. FEBS Lett. 2005; 579(21): 4678-84.
McIntyre NR, Lowe EW Jr, Chew GH, Owen TC, Merkler DJ. Thiorphan, tiopronin, and related analogs as substrates and inhibitors of peptidylglycine alpha-amidating monooxygenase (PAM). FEBS Lett. 2006; 580(2):521-32.
Weiss, SJ, McIntyre, NR, McLaughlin, ML, Merkler, DJ. The development of molecular clamps as drugs. Drug Discov. Today 2006; 11(17-18):819-24.
Merkler, DJ, Asser, AS, Baumgart, LE, Carballo, N, Carpenter, SE, Chew, GH, Cosner, CC, Dusi, J, Galloway, LC, Lowe, AB, Lowe, EW Jr., King III, L, Kendig, RD, Kline, PC, Malka, R, Merkler, KA, McIntyre, NR, Romero, M, Wilcox, BJ and Owen, TC. Substituted Hippurates and Hippurate Analogs as Substrates and Inhibitors of Peptidylglycine a-Hydroxylating Monooxygenase (PHM). Bioorg Med Chem. 2008; 16(23):10061-74.
McIntyre, N.R., Lowe, E.W. Jr., and Merkler, D.J. Imino-Oxy Acetic Acid Dealkylation as Evidence for an Inner-Sphere Alcohol Intermediate in the Reaction Catalyzed by Peptidylglycine a-Hydroxylating Monooxygenase (PHM). Journal of the American Chemical Society, 2009, 131(29):10308-19.
McIntyre, N.R., Lowe, E.W.Jr., Belof,J.L., Ivkovic, M., Shafer, J., Space, B. and Merkler, D.J. Evidence for Substrate Pre-organization in the Peptidylglycine a-Amidating Monooxygenase (PAM) Reaction Describing the Contribution of Ground State Structure to Hydrogen Tunneling. Submitted.