DEPARTMENT OF CHEMISTRY
 

 
FACULTY/Staff PROFILE
seporator

Maryam Foroozesh, Ph.D.
Chair, Division of Mathematical and Physical Sciences
Head, Department of Chemistry
Margaret W. Kelly Endowed Professor in Chemistry
NIH NIGMS RISE Program Director
NSF I-Cubed Program Director

Telephone Number: 504-520-5078
Room Number: NCF Annex - Room 331 & 335
Email Address: mforooze@xula.edu

 

Courses

Organic Chemistry and Toxicology

 

Short Professional Biography
Education:      
Institution     Field  Degree Year
Louisiana State University Chemistry B.S. 1990
Tulane University Chemistry/Organic/Bioorganic Ph.D. 1994

Appointments
July 2013-present Chair, Division of Mathematical and Physical Sciences
2012-present Margaret W. Kelly Endowed Professor in Chemistry
2012-present Head, Department of Chemistry
2007-2012 Times-Picayune/Samuel Newhouse Foundation Endowed Professor in Scientific Research
2006-2007 Professor of Chemistry, Xavier University of Louisiana, New Orleans LA
2000-2006 Associate Professor of Chemistry, Xavier University of Louisiana
2000-2002 Assistant Chair of Chemistry, Xavier University of Louisiana
1995-2000 Assistant Professor of Chemistry, Xavier University of Louisiana
1996-2000 Coordinator, Organic Chemistry Labs, Xavier University of Louisiana
1995-1995 Coordinator, Organic Chemistry Labs, Louisiana State University, Baton Rouge
1994-1995 Instructor of General and Organic Chemistry, Louisiana State University

 

Research Interest

Our research group currently focuses on two extensive projects:

  • We design, synthesize, and perform bioassays of potential inhibitors of cytochrome P450 enzymes, which are a superfamily of hemoproteins involved in metabolism and carcinogenesis. Previous studies in our lab have established that a number of aromatic acetylenes are selective suicide inhibitors of cytochrome P450-dependent monooxygenases. Due to the special properties of suicide inhibitors, these compounds are useful tools in the studies of cancer development and treatment. Additionally, the mechanism of action of these inhibitors makes it possible to use them as probes into the active sites of P450 enzymes leading to better understanding of the structure-activity relationships involved in the P450-dependent reactions; and to use the newly synthesized compounds as experimental tools in investigating the role of these P450 enzymes in the carcinogenesis process.
  • In recent years, breast cancer researchers have increasingly focused on the regulation of sphingolipid metabolism which has been shown to be closely related to cancer pathogenesis and drug resistance. Ceramide (the central molecule of sphingolipid pathway) regulation and metabolism were proved to be novel targets for anti-cancer drug design. Our group designs and synthesizes ceramide analogs as potential treatment for chemo- and endocrine-resistant breasts cancers. The anti-cancer activity of our novel analogs on breast cancer cell lines are studied by our collaborators at Tulane University. 

 

Current Grant Support

Project/Proposal Title: Multi-Target, Mechanism-Based Drug Design for the Treatment of Breast Cancer: Synthesis, Screening, and Mechanism Investigation of a Ceramide Analog Library
PI: Maryam Foroozesh, Ph.D.                                                             
Source of Support: NIH AREA
Period Covered:  March 1, 2011- Feb. 29, 2014  
The major goal of this project is to synthesize a library of ceramide derivatives, and perform a number of in vitro bioassays to study their structure-activity relationships to potential reversal of drug resistance in breast cancer cell lines.

Project/Proposal Title: Developing a Drug Discovery Program for Combined Breast Cancer Therapy
PI: Maryam Foroozesh, Ph.D.
Source of Support: DoD CDMRP
Period Covered:  Sep. 1, 2011- Aug. 31, 2015  
The major goal of this project is to develop a collaboration and training program between the Xavier University Drug Design Team and the Tulane University Cancer Biology Team.

Project/Proposal Title: Critical Juncture, STEM Educational Innovations Driven by Holistic, Integrative Evaluation Systems
PI: Loren Blanchard, Ph.D.               Co. PI: Maryam Foroozesh, Ph.D.
Source of Support:  NSF/Innovation through Institutional Integration (I-Cubed)
Period Covered:  June  1, 2010- May 31, 2015  
The program will integrate and enhance the University’s suite of core STEM bridge programs, which serve to attract underrepresented minority students into STEM fields and assist them in the transition from their high school studies through their first year of college.

Project/Proposal Title: RISE Option II at Xavier University of Louisiana
PI: Maryam Foroozesh, Ph.D.                                                             
Source of Support: NIH NIGMS MBRS-RISE
Period Covered:  August 15, 2012- July 31, 2017  

The RISE Program at Xavier is a student-training program preparing our undergraduate minority students for graduate school and the pursuit of research careers in biomedical fields.

 

Recent Publications

Publications (undergraduate authors are underlined):

“Metabolic Fate of the AH Receptor Ligand 6-Formylindolo[3,2-b]carbazole” L. Bergander, A. Rannug, E. Wincent, M. Foroozesh, W. Alworth, and U. Rannug, Chemico-Biological Interactions, 149: 151-64, 2004.

“Synthesis of a Family of Naphthyl Propargyl Ethers as Potential Cytochrome P450 Inhibitors” A.T. Kelley, J.Y. Mesbah, M.E. McKendall, T.P. Smith, and M. Foroozesh, Journal of Undergraduate Chemical Research, Vol. 3, pp. 103-105, 2004.

“Synthesis of a Family of Biphenylpropargyl Ethers as Potential Inhibitors of P450 Enzymes. X-Ray Crystal Structure of 2,2’-Biphenyldipropargyl Ether” B. Bowman, D. Lightsey, M. McKendall, T. Smith, N. Zhu, C. L. Klein Stevens, and M. Foroozesh, Journal of Undergraduate Chemical Research, Vol. 2, pp. 57-61, 2005.

“Naphthoflavone Propargyl Ether Inhibitors of Cytochrome P450” N. Zhu, D. Lightsey, M. Foroozesh, W. Alworth, A. Chaudhary, K. L. Willet, and C.K. Stevens, Journal of Chemical Crystallography, Vol. 36, No. 5, pp. 289-295, 2006.

“Methoxyflavone Inhibitors of Cytochrome P450”, M. McKendall, T. Smith, K. Ahn, J. Ellis, T. McGee, M. Foroozesh, N. Zhu, and C.L. Klein Stevens, Journal of Chemical Crystallography, Vol. 38, No. 4, pp. 231-237, 2008.

Differential Inhibition of P450s 3A4 and 3A5 By the Newly Synthesized Coumarin Derivatives, 7-Coumarin Propargyl Ether and 7-(4-Trifluoromethyl)coumarin Propargyl Ether”, C. Sridar, U.M. Kent, A. McCall, W.L. Alworth, M. Foroozesh, and P. Hollenberg, Drug Metabolism and Disposition, Vol. 36, pp. 2234-2243, 2008.

“Interaction of Polycyclic Aromatic Hydrocarbons with Human Cytochrome P450 1B1 in Inhibiting Catalytic Activity”, T. Shimada, N. Murayama, K. Tanaka, S. Takenaka, Y. Imai, N.E. Hopkins, M.K. Foroozesh, W.L. Alworth, H. Yamazaki, F.P. Guengerich, and M. Komori, Chemical Research in Toxicology, Vol. 21, No.12, pp. 2313-2323, 2008.

“Reverse Type I Binding Spectra of Human Cytochrome P450 1B1 Induced by Flavonoid, Stilbene, Pyrene, Naphthalene, Phenanthrene, and Biphenyl Derivatives that Inhibit Catalytic Activity: A Structure-Function Relationship Study”, T. Shimada, K. Tanaka, S. Takenaka, M.K. Foroozesh, N. Murayama, H. Yamazaki, F.P. Guengerich, and M. Komori, Chemical Research in Toxicology, Vol. 22, No. 7, pp. 1325-1333, 2009.

“Design, Synthesis, and Biological Activity of a Family of Novel Ceramide Analogs in Chemoresistant Breast Cancer Cells”, J.W. Antoon, J. Liu, M.M. Gestaut, M.E. Burow, B.S. Beckman, and M. Foroozesh, Journal of Medicinal Chemistry, Vol. 52, No. 18, pp.  5748–5752, 2009.

“Ethynyl and Propynyl Pyrene Inhibitors of Cytochrome P450”, N. Zhu, D. Lightsey, J. Liu, M. Foroozesh, K.M. Morgan, E. D. Stevens, and C.L.K. Stevens, Journal of Chemical Crystallography, Vol. 40, pp. 343-352, 2010.

“In Silico Studies to Determine Structural Features Influencing Polyaromatic Hydrocarbon Inhibition Potency of Cytochrome P450 enzymes 1A1, 1A2, 2A6 and 2B1”, J. Sridhar, P. Jin, J. Liu, M. Foroozesh, and C. Stevens, Chemical Research in Toxicology, Vol. 23, No. 3, pp. 600–607, 2010.

“Novel D-erythro N-Octanoyl Sphingosine Analogues As Chemo- and Endocrine Resistant Breast Cancer Therapeutics”, J. Antoon, J. Liu, A. Ponnapakkam, M. Foroozesh, and B. Beckman, Cancer Chemotherapy and Pharmacology, Vol. 65, No. 6, pp. 1191-1195, 2010.

“Novel Anti-Proliferative Ceramide Analogs: Design, Synthesis, and Structure-Activity Relationship Studies of Substituted (S)-2-(Benzylideneamino)-3-hydroxy-N-tetradecylpropanamides”, J. Liu, J.W. Antoon, A. Ponnapakkam, B.S. Beckman, and Maryam Foroozesh, accepted for publication in Bioorganic and Medicinal Chemistry, Vol. 18, No. 14, pp. 5316-5322, 2010.

“Structure-Function Relationships of Inhibition of Human Cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 Flavonoid Derivatives”, T. Shimada, K. Tanaka, S. Takenaka, N. Murayama, M. Martin, M.K. Foroozesh, H. Yamazaki, F.P. Guengerich, and M. Komori, Chemical Research in Toxicology, Vol. 23, No.12, pp. 1921–1935, 2010.

“QSAR Models of Cytochrome P450 Enzyme 1A2 Inhibitors using CoMFA, CoMSIA, and HQSAR”, J. Sridhar, M. Foroozesh, and C.L.K. Stevens, SAR and QSAR in Environmental Research, Vol. 22, No. 7-8, pp. 681-97, 2011.

“Inhibition of Cytochrome P450 Enzymes by Quinones and Anthraquinones”, J. Sridhar, J. Liu, M. Foroozesh, and C.L.K. Stevens, Chemical Research in Toxicology, Vol. 25, No. 2, pp. 357-65, 2012.

“7-Ethynylcoumarins: Selective Inhibitors of Human Cytochrome P450s 1A1 and 1A2”, J. Liu, T. Nguyen, P.S. Dupart, J. Sridhar, X. Zhang, N. Zhu, C. L.K. Stevens, and M. Foroozesh, Chemical Research in Toxicology, Vol. 25, No. 5, pp. 1047-1057, 2012.

“Insight on the Cytochrome P450 Enzymes and Inhibitors Obtained Through QSAR Studies”, J. Sridhar, J. Liu, M. Foroozesh, and C.L.K. Stevens, Molecules, Vol. 17, pp. 9283-9305, 2012. 

“Potent Mechanism-Based Inactivation Of Cytochrome P450 2B4 By 9-Ethynyl phenanthrene: Implications For Allosteric Modulation Of Cytochrome P450 Catalysis”, H. Zhang, S. Gay, M. Shah, M. Foroozesh, J. Liu, Y. Osawa, Q. Zhang^, C.D. Stout^, J.R. Halpert, and P.F. Hollenberg, Biochemistry, Vol. 52, No. 2, pp. 355-364, 2013.

“Binding of Diverse Environmental Chemicals with Human Cytochromes P450 2A13, 2A6, and 1B1 and Enzyme Inhibition”, T. Shimada, D. Kim, N. Murayama, K. Tanaka, S. Takenaka, L.D. Nagy, L.M. Folkman, M.K. Foroozesh, M. Komori, H. Yamazaki, and F.P. Guengerich, Chemical Research in Toxicology, Vol. 26, pp. 517−528, 2013. 

“Development of Flavone Propargyl Ethers as Potent and Selective Inhibitors of Cytochrome P450 Enzymes 1A1 and 1A2”, J. Sridhar, J. Ellis, P. Dupart, J. Liu, C.L.K. Stevens, and M. Foroozesh, Drug Metabolism Letters, Mar 15 2013. [Epub ahead of print]. 

"Pyranoflavones: A Group of Small-molecule Probes for Exploring the Active Site Cavities of Cytochrome P450 Enzymes 1A1, 1A2, and 1B1", J. Liu, S. Taylor, P. Dupart, C. Arnold, J. Sridhar, Q. Jiang, Y. Wang, M. Zhao, and M. Foroozesh,Journal of Medicinal Chemistry, Vol. 56, No. 10, pp. 4082–4092, 2013. 

“A Review of Ceramide Analogs as Potential Anticancer Agents”, J. Liu, B.S. Beckman, and M. Foroozesh,  Future Med Chem, Vol. 5, No. 12, pp. 1405-1421, 2013.

“Cytochrome P450 Family 1 Inhibitors and Structure-Activity Relationship”, J. Liu, J. Sridhar, and M. Foroozesh, Molecules, Vol. 18, pp. 14470-14495, 2013.

“Design, Synthesis, and Evaluation of a Family of Propargyl Pyridinyl Ethers as Potential Cytochrome P450 Inhibitors”, M. Foroozesh, Q. Jiang, J. Sridhar, J. Liu, Minaruzzaman, B. Dotson, and E. McClain, Journal of Undergraduate Chemistry Research, Vol. 12, No. 4, pp. 92-95, 2013. 
“Design, and Synthesis of Carbazole Analogs As Potential Cytochrome P450 Inhibitors”, M. Foroozesh, Q. Jiang, J. Sridhar, J. Liu, B. Dotson, and E. McClain, Journal of Undergraduate Chemistry Research, Vol. 12, No. 4, pp. 89-91, 2013. 

“3-Ketone-4,6-diene Ceramide Analogs Exclusively Induce Apoptosis in Chemo-resistant Cancer Cells”, A. Ponnapakkam, J. Liu, B.A. Drew, T.L. Wang, J.W. Antoon, T.T. Nguyen, P.S. Dupart, M. Foroozesh, and B.S. Beckman, Bioorganic and Medicinal Chem., Vol. 22, No. 4, pp. 1412-1420, 2014.  PMCID: PMC3967587.

“Innovative Improvements in the Introductory Chemistry and Physics Courses at Xavier University of Louisiana” D. Richardson, M. Adams, M. Foroozesh, and T.S. Coston, submitted to the Journal of College Science Teaching, June 2014.

“Innovation Through Institutional Integration (I-Cubed) Program at Xavier University of Louisiana”, L. Blanchard, M. Foroozesh, T.S. Coston, And E.Y. Hammer, EDULearn Proceedings, International Academy of Technology, Education and Development (IATED) Digital Library, July 2014.

“Ethynylflavones, Highly Potent and Selective Inhibitors of Cytochrome P450 1A1”, N. Goyal, J. Liu, L. Lovings, P. Dupart, S. Taylor, S. Bellow, L. Mensah, E. McClain, B. Dotson, J. Sridhar, X. Zhang, M. Zhao, and M Foroozesh, Chemical Research in Toxicology, Vol. 27, No.8, pp. 1431–1439, 2014.

“Innovation Through Institutional Integration (I-Cubed) Program at Xavier University of Louisiana”, L. Blanchard, M. Foroozesh, T.S. Coston, and E.Y. Hammer, Submitted to Journal of Negro Education, the White House Initiative, July 2014. 

“Catalytic Specificity of Human Cytochrome P450 2A13 in Oxidative Metabolism of Pyrene, 1-Hydroxypyrene, 1-Nitropyrene, and 1-Acetylpyrene”, T. Shimada, S. Takenaka, N. Murayama, V.M. Kramlinger, J.-H. Kim, D. Kim, J. Liu, M.K. Foroozesh, H. Yamazaki, F. P. Guengerich, and M. Komori, Submitted to Chemical Research in Toxicology, October 2014.

Presentations (undergraduate presenters are underlined):

“Differential Inhibition of P450s 3A4 and 3A5 by 7-Coumarin Propargyl Ether and 7-(Trifluro)coumarin Propargyl Ether”, C. Stridar, U.M. Kent, M. Foroozesh, W. Alworth, and P.F. Hollenberg, ISSX Annual Meeting, Vancouver, Canada, August 2004.

“Synthesis of Phenanthrene Derivatives”, S. Trice, and M. Foroozesh, ACS Local Section Student Poster Presentation, New Orleans, October 2004.

“Biphenyl Propargyl Ethers as Inhibitors of CYP1A1, CYP1A2, and CYP2B1”, N. Hopkins, B. Bowman, T. Smith, C. DeCuir-Charbonnet, A. Henderson, and M. Foroozesh, Society of Toxicology 44th Annual Meeting, New Orleans, March 2005.
 
“Synthesis of Phenanthrene Derivatives as Cytochrome P450 Inhibitors”, S. Trice, and M. Foroozesh, NOBCChE National conference, Orlando, Florida, March 2005.

“Phenanthrene Derivatives as Cytochrome P450 Inhibitors”, S. Trice, and M. Foroozesh, Festival of Scholars at Xavier university of Louisiana, New Orleans, March 2006.

“Synthesis of a New family of Benzoate Esters with Potential Biological Activities”, Q. Nhan, and M. Foroozesh, ACS Local Section Student Poster Presentation, New Orleans, September 2006, and Pfizer Pharmaceuticals Meeting, October 2006.

“Synthesis of Coumarin Derivatives as Potential Cytochrome P450 Inhibitors”, A. McCall, and M. Foroozesh, ACS Local Section Student Poster Presentation, New Orleans, September 2006.

“Synthesis of Pyridine Propargyl Ethers”, J. Ellis, and M. Foroozesh, ACS Local Section Student Poster Presentation, New Orleans, September 2006.

“Synthesis of Coumarin Derivatives as Potential Cytochrome P450 Inhibitors”, A. McCall, and M. Foroozesh, ABRCMS Meeting, Anaheim, California, November 2006.

“Synthesis of Benzoate Esters with Potential Biological Activity”, Q. Nhan, R. Colvin, T. McGee, and M. Foroozesh, ACS National Meeting, Chicago, IL, March 2007.

“Synthesis of a New Series of Coumarin Derivatives as Potential Cytochrome P450 Inhibitors”, A. McCall, A. Norris, and M. Foroozesh, ACS National Meeting, Chicago, IL, March 2007.

“Pyridylpropargyl Ethers as Cytochrome P450 Inhibitors”, J. Ellis, and M. Foroozesh, ACS Local Section Student Poster Presentation, New Orleans, October 2007, and Pfizer Pharmaceuticals Meeting, September 2007.

“Synthesis of a New Family of Flavonoids as Potential Cytochrome P450 Inhibitors”, J. Monroe, and M. Foroozesh, Annual Meeting of the South Central Chapter of Society of Toxicology, Oxford, MS, September 2007.

“Design, Synthesis, and Bioassays of New Families of Compounds as Potential Inhibitors of Cytochrome P450 Enzymes”, M. Foroozesh, invited talk at Louisiana State University Department of Chemistry, Baton Rouge, LA, October 2007.

“Potential Reversal of Drug Resistance in Breast Cancer Cells Using Ceramide Derivatives”, B. Beckman, M. Burow, and M. Foroozesh, LCRC Retreat, New Orleans, LA, February 2008.
 
“Docking Studies of a Family of Methoxyflavones”, P. Jin, C. Stevens, and M. Foroozesh, Society of Toxicology Meeting, Seattle, WA, March 2008.

“Pyridine Derivatives as Potential P450 Inhibitors”, J.A. Ellis, and M. Foroozesh, ACS National Meeting, New Orleans, LA, April 2008.

“Synthesis of Flavonoids as Potential P450 Inhibitors”, J. Monroe, and M. Foroozesh, ACS National Meeting, New Orleans, LA, April 2008.

“Pyridine Derivatives as Potential P450 Inhibitors”, J.A. Ellis, and M. Foroozesh, Festival of Scholars, Xavier University, New Orleans, LA, April 2008.

“Synthesis of Flavonoids as Potential P450 Inhibitors”, J. Monroe, and M. Foroozesh, Festival of Scholars, Xavier University, New Orleans, LA, April 2008.

“Coumarin Derivatives as Potential Cytochrome P450 Inhibitors”, A.R. Simpson, J.A. Ellis, and M. Foroozesh, ACS Local Section Student Poster Presentation, New Orleans, October 2008.

“Synthesis of Pyridine Propargyl Ethers as Potential P450 Inhibitors”, J. Ellis, and M. Foroozesh, ACS Local Section Student Poster Presentation, New Orleans, October 2008.

“Synthesis of Flavonoid P450 Inhibitors”, J. Monroe, J.A. Ellis, and M. Foroozesh, ACS Local Section Student Poster Presentation, New Orleans, October 2008.

“Novel Ceramide Analogs as Anti-cancer Agents”, J.W. Antoon, J. Liu, M.M. Gestaut, B.S. Beckman, and M. Foroozesh, Tulane Health Science Research Days, Tulane University, New Orleans, LA, February 2009.

“Novel Ceramide Analogs as Anti-cancer Agents: Design, Synthesis, and Cytotoxic Activity in Chemoresistant Breast Cancer””, J.W. Antoon, J. Liu, M.M. Gestaut, B.S. Beckman, and M. Foroozesh, Fifth International Charleston Ceramide Conference, Charleston, N.C., March 2009.

“Molecular Structure, Inhibition, and Docking Studies of a Family of Polyaromatic Hydrocarbons”, C.L. Klein Stevens, J. Sridhar, P. Jin, J. Liu, N. Zhu, and M. Foroozesh, American Chemical Society National Meeting, Salt lake City, Utah, March 2009.

“Novel Ceramide Analogs as Anti-cancer Agents: Design, Synthesis, and Cytotoxic Activity in Chemoresistant Breast Cancer””, J.W. Antoon, J. Liu, M.M. Gestaut, B.S. Beckman, and M. Foroozesh, Louisiana Cancer Research Consortium Annual Retreat, New Orleans, LA, March 2009.

“Molecular Structure, Inhibition, and Docking Studies of a Family of Polyaromatic Hydrocarbons”, C.L. Klein Stevens, J. Sridhar, P. Jin, J. Liu, N. Zhu, and M. Foroozesh, Louisiana Cancer Research Consortium Annual Retreat, New Orleans, LA, March 2009.

“Synthesis of Two Methoxyflavone as Potential P450 Suicide Inhibitors”, S. Anderson, J.A. Ellis, and M. Foroozesh, ACS Local Section Student Poster Presentation, New Orleans, LA, October 2009.

“Benzoate Esters as P450 Inhibitors”, C.W. Wusthoff, J.A. Ellis, and M. Foroozesh, ACS Local Section Student Poster Presentation, New Orleans, LA, October 2009.

“Coumarin Derivatives as Potential Cytochrome P450 Inhibitors”, T.C. Bellot, J.A. Ellis, and M. Foroozesh, ACS Local Section Student Poster Presentation, New Orleans, LA, October 2009.

“Coumarin Derivatives as Potential Cytochrome P450 Inhibitors”, T.C. Bellot, J.A. Ellis, and M. Foroozesh, Annual Biomedical Research Conference for Minority Students (ABRCMS), Phoenix, AZ, November 2009.
 
“Novel Anti-Proliferative Ceramide Analogs: Design, Synthesis, and Structure-Activity Relationship Studies of Substituted (S)-2-(Benzylideneamino)-3-hydroxy-N-tertradecylpropanamides”, J. Liu, J.W. Antoon, A. Ponnapakkam, B.S. Beckman, and M. Foroozesh, Louisiana Cancer Research Consortium Annual Retreat, New Orleans, LA, March 2010.

“Sphingolipid Metabolism as a Therapeutic Target in Chemotherapy-Resistant and Hormone Therapy-Resistant Breast Cancer”, M.M. Gestaut, J.W. Antoon, A.P. Ponnapakkam, J. Liu, M.E. Burow, M. Foroozesh, and B.S. Beckman, Louisiana Cancer Research Consortium Annual Retreat, New Orleans, LA, March 2010.

“Factors Influencing Inhibition Potency of Propargyl Substituted Compounds Against Cytochrome P450 Enzymes 1A1, 1A2, and 2B1”, J. Sridhar, J. Liu, M. Foroozesh, and C.L.K. Stevens, Louisiana Cancer Research Consortium Annual Retreat, New Orleans, LA, March 2010.

“Synthesis of Methoxyflavones as Potential P450 Suicide Inhibitors”, S. Anderson, J.A. Ellis, and M. Foroozesh, Festival of Scholars, Xavier University, New Orleans, LA, April 2010.

“Coumarin Derivatives as Potential Cytochrome P450 Inhibitors”, T. Bellot, J.A. Ellis, and M. Foroozesh, Festival of Scholars, Xavier University, New Orleans, LA, April 2010.

“Pyridine Derivatives as Potential Cytochrome P450 Inhibitors”, K. Williams, J.A. Ellis, and M. Foroozesh, Festival of Scholars, Xavier University, New Orleans, LA, April 2010.

“Sphingolipid Metabolism as a Therapeutic Target in Chemotherapy-Resistant and Hormone Therapy-Resistant Breast Cancer”, M.M. Gestaut, J.W. Antoon, A.P. Ponnapakkam, J. Liu, M.E. Burow, M. Foroozesh, and B.S. Beckman, American Association for Cancer Research Meeting, Washington, D.C., April 2010.

“Benzoate Esters as P450 Inhibitors”, C.W. Wusthoff, J.A. Ellis, and M. Foroozesh, ACS Local Section Student Poster Presentation, New Orleans, LA, October 2010.
 
“Structure-Function Relationships of Inhibition of Human Cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 Flavonoid Derivatives”, T. Shimada, K. Tanaka, S. Takenaka, N. Murayama, M. Martin, M.K. Foroozesh, H. Yamazaki, F.P. Guengerich, and M. Komori, 25th Annual Meeting of the Japanese Society for the Study of Xenobiotics, October 2010.
 
“Benzoate Esters as Cytochrome P450 Inhibitors”, P. Dupart, J.A. Ellis, and M. Foroozesh, ACS Local Section Student Poster Presentation, New Orleans, LA, October 2010 &Festival of Scholars, Xavier University, New Orleans, LA, April 2011.
 
“Synthesis of Methoxyflavones as Potential P450 Suicide Inhibitors”, S. Anderson, J.A. Ellis, and M. Foroozesh, ACS Local Section Student Poster Presentation, New Orleans, LA, October 2010 &Festival of Scholars, Xavier University, New Orleans, LA, April 2011.
 
“Synthesis of Methoxy Dihydroxy Flavones as Potential P450 Suicide Inhibitors”, S. Anderson, J.A. Ellis, and M. Foroozesh, 66th Southwest and 62nd Southeastern Regional Meetings of the American Chemical Society, New Orleans, December 2010 &Festival of Scholars, Xavier University, New Orleans, LA, April 2011.
 
“Benzoate Esters as Potential Cytochrome P450 Inhibitors”, P. Dupart, J.A. Ellis, and M. Foroozesh, 66th Southwest and 62nd Southeastern Regional Meetings of the American Chemical Society, New Orleans, December 2010.

“Pyridine Derivatives as Cytochrome P450 Inhibitors”, K. Williams, J.A. Ellis, and M. Foroozesh, ACS Local Section Student Poster Presentation, New Orleans, LA, October 2010.

“Pyridine Derivatives as Potential Cytochrome P450 Inhibitors”, K. Williams, J.A. Ellis, and M. Foroozesh, 66th Southwest and 62nd Southeastern Regional Meetings of the American Chemical Society, New Orleans, December 2010  & Festival of Scholars, Xavier University, New Orleans, LA, April 2011.

“A Novel Family of Ceramide Analogs Blocks Survival in Metastatic Ovarian Cancer in Vitro”, B.A. Dew, A.P. Ponnapakkam, T.L. Wang, J. Liu, M. Foroozesh, and B.S. Beckman, Tulane University Health Sciences Research Days, April 2011.

“A Novel Ceramide Analog Inhibits Survival in Pancreatic Cancer Cells”, T.L. Wang, B.A. Dew, J. Liu, M. Foroozesh, and B.S. Beckman, Tulane University Health Sciences Research Days, April 2011.

“Novel Ceramide Analogs for the Treatment of Breast Cancer”, A.P. Ponnapakkam, B.A. Dew, T.L. Wang, J. Liu, M. Foroozesh, and B.S. Beckman, Tulane University Health Sciences Research Days, April 2011.

“The Build-up of an Anti-cancer Activities-targeted Ceramide Analog Library”, J. Liu, B.S. Beckman, and M. Foroozesh, Annual Louisiana Cancer Research Consortium Scientific Retreat, April 2011.

“Design, Synthesis and Inhibition Studies of 7-Ethynyl-Coumarin Derivatives as Potential Inhibitors for Cytochrome P450 1A2”, T. Nguyen, J. Liu, and M. Foroozesh, American Chemical Society Local Section Student Poster Presentation, New Orleans, LA, September 2011.

“Novel Ceramide Analogs for the Treatment of Breast Cancer”, A.P. Ponnapakkam, B.A. Drew, T.L. Wang, L. Liu, M. Foroozesh, and B.S. Beckman, Advances in Breast Cancer Research: Genetics, Biology, and Clinical Applications Conference, American Association for Cancer Research, San Francisco, CA, October 2011.

“Synthesis of Nicotine Analogs”, S. Johnson, M. Minaruzzaman, and M. Foroozesh, Annual Biomedical Research Conference for Minority Students, St. Louis, MI, November 2011.

“Emodin Analogs as Cytochrome P450 Inhibitors- A Study of Their Potency and Selectivity”, J. Sridhar, J. Liu, C.L.K. Stevens, and M. Foroozesh, Society of Toxicology National Meeting, San Francisco, CA, March 2012, and Louisiana Cancer Research Consortium Annual Retreat Meeting, March 2012.

“7-Ethynylcoumarins Selectively Inhibiting P450s 1A1 and 1A2”, J. Liu, T. Nguyen, J. Sridhar, C.L.K. Stevens, and M. Foroozesh, Louisiana Cancer Research Consortium Annual Retreat Meeting, March 2012.

“Development of Flavone Propargyl Ethers as Potent and Selective Inhibitors of Cytochrome P450 Enzymes 1A1 and 1A2”, J. Sridhar, J. Liu, C.L.K. Stevens, and M. Foroozesh, Louisiana Cancer Research Consortium Annual Retreat Meeting, March 2012.

“Novel Ceramide Analogs for the Treatment of Breast Cancer”, A.P. Ponnapakkam, B.A. Drew, T.L. wang, J. Liu, M. Foroozesh, and B.S. Beckman, Louisiana Cancer Research Consortium Annual Retreat Meeting, March 2012.

“Design, Synthesis and Inhibition Studies of 7-Ethynyl-Coumarin Derivatives as Potential Inhibitors for Cytochrome P450s 1A1, 1A2, 2B1, and 2A6”, T. Nguyen, J. Liu, and M. Foroozesh, American Chemical Society National Meeting, San Diego, CA, March 2012, and Festival of Scholars, Xavier University, New Orleans, LA, April 2012.

“Flavone Derivatives as Potential Suicide Inhibitors for Cytochrome P450 Enzymes” M. Collins, T. Mangnum, P. Dupart, J. Liu, and M. Foroozesh, Festival of Scholars, Xavier University, New Orleans, LA, April 2012.

“Homotropic Cooperativity During the Mechanism-Based Inactivation of Cytochrome P450 2B4 by 9-Ethynylphenanthrene”, H. Zhang, S. Gay, M. Shah, M. Foroozesh, J.R. Halpert, and P.F. Hollenberg, Experimental Biology Meeting, San Diego, CA, April 2012.

“The Design and Synthesis of Benzoate Esters as Potential Anti-proliferation Agents and Inhibitors of Cytochrome P450 Enzymes”, C. Arnould, P. Dupart, J. Liu, and M. Foroozesh, the Annual LaSPACE Council Meeting, and the American Chemical Society Local Section Student Poster Presentation, New Orleans, LA, October 2012.

“Propargyl Flavones as Inhibitors of Human Cytochrome P450s 1A1, and 1A2”, S. Taylor, J. Liu, P. Dupart, and M. Foroozesh, the American Chemical Society Local Section Student Poster Presentation, New Orleans, LA, October 2012.

“Quest for New Mechanism-Based Inhibitors of Cytochrome P450 Enzymes 1A1 and 1A2”, J. Sridhar, J. Liu, M. Foroozesh, C.L. Stevens, the Louisiana Cancer Research Consortium Annual Retreat, New Orleans, LA, March 2013.

“Pyranoflavones and 5-Hydroxy-pyranoflavones as Small-molecule Probes into the Active Site Cavities of P450s 1A1 and 1A2”, J. Liu, S. Taylor, P. Dupart, C. Arnold, and M. Foroozesh, the Louisiana Cancer Research Consortium Annual Retreat, New Orleans, LA, March 2013.

Design, Synthesis and Evaluation of 3-Oxy-substituted Pyridine Terminal Alkynes”, Q. Jiang, J. Sridhar, M. Minaruzzaman, J. Liu, and M. Foroozesh, the Louisiana Cancer Research Consortium Annual Retreat, New Orleans, LA, March 2013.

“Design, Synthesis, and Bioassays of Potential P450 Inhibitors”, M. Foroozesh, Invited Oral Presentation at the American Chemical Society National Meeting, New Orleans, LA, April 2013.

“Quest for New Mechanism-Based Inhibitors of Cytochrome P450 Enzymes 1A1 and 1A2”, J. Sridhar, J. Liu, M. Foroozesh, C.L. Stevens, the American Chemical Society National Meeting, New Orleans, LA, April 2013. 

“The Design and Synthesis of Benzoate Esters as Potential Anti-prolifearion Agents and Inhibitors of Cytochrome P450 Enzymes”, C. TutwilerC. Arnold, P. Dupart, J. Liu, and M. Foroozesh, the American Chemical Society National Meeting, New Orleans, LA, April 2013.

“Ethynyl Flavones as Inhibitors of Cytochrome P450 Enzymes”, S. Taylor, J. Liu, P. Dupart, and M. Foroozesh, the American Chemical Society National Meeting, New Orleans, LA, April 2013.

“Flavone Derivatives as Small-molecule Probes of Cytochrome P450 Enzymes: Inhibitory Activity and Selectivity”, J. Liu, S. Taylor, P. Dupart, C. Arnold, and M. Foroozesh, the American Association for Cancer Research Annual Meeting, Washington, D.C., April 2013.

“The Design and Synthesis of Isothiocyanate Flavones as Potential Anti-proliferation Agents and Inhibitors of Cytochrome P450 Enzymes”, B. Dotson, J. Liu, and M. Foroozesh, the American Chemical Society National Meeting, Dallas, TX, March 2014.

“Synthesis of Resorufin Derivatives as Inhibitor Indicators of Cytochrome P450 Enzymes”, L. Lovings, J. Liu, and M. Foroozesh, the American Chemical Society National Meeting, Dallas, TX, March 2014.

“Design and Synthesis of Flavonoids as Potential Inhibitors of Human Cytochrome P450 1A1 and 1A2 Enzymes”, L. Mensah, J. Liu, L. Lovings, and M. Foroozesh, the American Chemical Society National Meeting, Dallas, TX, March 2014.

“The Design and Synthesis of Benzoate Esters as Potential Anti-proliferation Agents and Inhibitors of Cytochrome P450 Enzymes”, E. McClain, L. Lovings, and M. Foroozesh, the American Chemical Society National Meeting, Dallas, TX, March 2014.

“The Design and Synthesis of Resorufin propargyl Ethers as Potential Cytochrome P450 Inhibitors”, S. Bellow, L. Lovings, J. Liu, and M. Foroozesh, the American Chemical Society National Meeting, Dallas, TX, March 2014.

“Synthesis and Biological Studies of a New Series of Ethynylflavones as Cytochrome P450 Inhibitors”, N. Goyal, J. Liu, and M. Foroozesh, the Louisiana Cancer Research Consortium Annual Retreat, New Orleans, LA, March 2014.

“Ceramide Analogs as Resistant Cancer Cell Killing Agents, and Their Ability to Inhibit Glucosylceramide Synthase”, J. Liu, A. Ponnapakam, K. Bhinge, Y.-Y. Liu, B. Beckman, and M. Foroozesh, the Louisiana Cancer Research Consortium Annual Retreat, New Orleans, LA, March 2014.

“Innovation Through Institutional Integration (I-Cubed) Program at Xavier University of Louisiana”, L. Blanchard, M. Foroozesh, T.S. Coston, And E.Y. Hammer, EDULearn Meeting, Barcelona, Spain, July 2014.


 

 
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