Department of Chemistry

Xavier University of Louisiana

Maryam Foroozesh, Ph.D.
Chair, Division of Mathematical and Physical Sciences
Chair, Division of Biological and Applied Health Sciences
Head, Department of Chemistry
Margaret W. Kelly Endowed Professor in Chemistry
NIH NIGMS RISE Program Director
NSF I-Cubed Program Director

Telephone Number: 504-520-5078
Room Number: NCF Annex - Room 331 & 335
Email Address: mforooze@xula.edu
Courses

Organic Chemistry and Toxicology

Short Professional Biography
Education:
Institution Field Degree Year
Louisiana State University Chemistry B.S. 1990
Tulane University Chemistry/Organic/Bioorganic Ph.D. 1994

Appointments
2012-present Head, Department of Chemistry
2007-2012 Times-Picayune/Samuel Newhouse Foundation Endowed Professor in       Scientific Research
2006-2007 Professor of Chemistry, Xavier University of Louisiana, New Orleans LA
2000-2006 Associate Professor of Chemistry, Xavier University of Louisiana
2000-2002 Assistant Chair of Chemistry, Xavier University of Louisiana
1995-2000 Assistant Professor of Chemistry, Xavier University of Louisiana
1996-2000 Coordinator, Organic Chemistry Labs, Xavier University of Louisiana
1995-1995 Coordinator, Organic Chemistry Labs, Louisiana State University, Baton Rouge
1994-1995 Instructor of General and Organic Chemistry, Louisiana State University

Research Interest

Our research group currently focuses on two extensive projects:

  1. We design, synthesize, and perform bioassays of potential inhibitors of cytochrome P450 enzymes, which are a superfamily of hemoproteins involved in metabolism and carcinogenesis. Previous studies in our lab have established that a number of aromatic acetylenes are selective suicide inhibitors of cytochrome P450-dependent monooxygenases. Due to the special properties of suicide inhibitors, these compounds are useful tools in the studies of cancer development and treatment. Additionally, the mechanism of action of these inhibitors makes it possible to use them as probes into the active sites of P450 enzymes leading to better understanding of the structure-activity relationships involved in the P450-dependent reactions; and to use the newly synthesized compounds as experimental tools in investigating the role of these P450 enzymes in the carcinogenesis process.
  2. In recent years, breast cancer researchers have increasingly focused on the regulation of sphingolipid metabolism which has been shown to be closely related to cancer pathogenesis and drug resistance. Ceramide (the central molecule of sphingolipid pathway) regulation and metabolism were proved to be novel targets for anti-cancer drug design. Our group designs and synthesizes ceramide analogs as potential treatment for chemo- and endocrine-resistant breasts cancers. The anti-cancer activity of our novel analogs on breast cancer cell lines are studied by our collaborators at Tulane University.

Current Grant Support

PIs: Maryam Foroozesh, Marguerite Giguette, and Kathleen Morgan
Co-PI (Administration and Research Enrichment Core Director): Maryam Foroozesh, Ph.D.                    Project/Proposal Title: Building Integrated Pathways to Independence for Diverse Biomedical Researchers
Source of Support: NIH NIGMS Building Infrastructure Leading to Diversity (BUILD)
Period Covered:  September 26, 2014 - June 30, 2019
The BUILD Program at Xavier is a student-training, research enrichment, and institutional development program preparing our undergraduate minority students and faculty for pursuit of competitive research careers in biomedical fields. The ultimate goal of the Research Enrichment Core is to implement a highly-integrated series of activities to improve instruction in the STEM disciplines and move students into biomedical research careers.  

PI: Maryam Foroozesh                                                                       
Project/Proposal Title: RISE Option II at Xavier University of Louisiana
Source of Support: NIH NIGMS Research Initiative for Scientific Enhancement (RISE)
Period Covered:  August 1, 2012- July 31, 2017  

The RISE Program at Xavier is a student-training program preparing our undergraduate minority students for graduate school and the pursuit of research careers in biomedical fields.

Recent Publications (undergraduate authors are underlined):

            “Ethynyl and Propynyl Pyrene Inhibitors of Cytochrome P450”, N. Zhu, D. Lightsey, J. Liu, M. Foroozesh, K.M. Morgan, E.D. Stevens, and C.L.K. Stevens, Journal of Chemical Crystallography, Vol. 40, pp. 343-352, 2010. PMID: 20473363

            “In Silico Studies to Determine Structural Features Influencing Polyaromatic Hydrocarbon Inhibition Potency of Cytochrome P450 enzymes 1A1, 1A2, 2A6 and 2B1”, J. Sridhar, P. Jin, J. Liu, M. Foroozesh, and C.L.K. Stevens, Chemical Research in Toxicology, Vol. 23, No. 3, pp. 600–607, 2010. PMID: 20078084

“Novel D-erythro N-Octanoyl Sphingosine Analogues As Chemo- and Endocrine Resistant Breast Cancer Therapeutics”, J. Antoon, J. Liu, A. Ponnapakkam, M. Foroozesh, and B. Beckman, Cancer Chemotherapy and Pharmacology, Vol. 65, No. 6, pp. 1191-1195, 2010. PMID: 20155475

            “Novel Anti-Viability Ceramide Analogs: Design, Synthesis, and Structure-Activity Relationship Studies of Substituted (S)-2-(Benzylideneamino)-3-hydroxy-N-tetradecylpropanamides”, J. Liu, J.W. Antoon, A. Ponnapakkam, B.S. Beckman, and Maryam Foroozesh, Bioorganic and Medicinal Chemistry, Vol. 18, No. 14, pp. 5316-5322, 2010. PMID: 20639111

            “Structure-Function Relationships of Inhibition of Human Cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 Flavonoid Derivatives”, T. Shimada, K. Tanaka, S. Takenaka, N. Murayama, M. Martin, M.K. Foroozesh, H. Yamazaki, F.P. Guengerich, and M. Komori, Chemical Research in Toxicology, Vol. 23, No.12, pp. 1921–1935, 2010. PMID: 21053930

            “QSAR Models of Cytochrome P450 Enzyme 1A2 Inhibitors using CoMFA, CoMSIA, and HQSAR”, J. Sridhar, M. Foroozesh, and C.L.K. Stevens, SAR and QSAR in Environmental Research, Vol. 22, No. 7-8, pp. 681-97, 2011. PMID: 22004550, PMCID: PMC3371641.

            “Inhibition of Cytochrome P450 Enzymes by Quinones and Anthraquinones”, J. Sridhar, J. Liu, M. Foroozesh, and C.L.K. Stevens, Chemical Research in Toxicology, Vol. 25, No. 2, pp. 357-65, 2012. PMID: 22185593

            “7-Ethynylcoumarins: Selective Inhibitors of Human Cytochrome P450s 1A1 and 1A2”, J. Liu, T. Nguyen, P.S. Dupart, J. Sridhar, X. Zhang, N. Zhu, C. L.K. Stevens, and M. Foroozesh, Chemical Research in Toxicology, Vol. 25, No. 5, pp. 1047-1057, 2012. PMID: 22443586, PMCID: PMC3358478.

“Insight on the Cytochrome P450 Enzymes and Inhibitors Obtained Through QSAR Studies”, J. Sridhar, J. Liu, M. Foroozesh, and C.L.K. Stevens, Molecules, Vol. 17, pp. 9283-9305, 2012. PMID: 22864238

“Development of Flavone Propargyl Ethers as Potent and Selective Inhibitors of Cytochrome P450 Enzymes 1A1 and 1A2”, J. Sridhar, J. Ellis, P. Dupart, J. Liu, C.L.K. Stevens, and M. Foroozesh, Drug Metabolism Letters, Vol. 6, No. 4, pp. 275-284, 2012. PMID: 23506553, PMCID PMC4180220.

            “Potent Mechanism-Based Inactivation Of Cytochrome P450 2B4 By 9-Ethynyl phenanthrene: Implications For Allosteric Modulation Of Cytochrome P450 Catalysis”, H. Zhang, S. Gay, M. Shah, M. Foroozesh, J. Liu, Y. Osawa, Q. Zhang^, C.D. Stout^, J.R. Halpert, and P.F. Hollenberg, Biochemistry, Vol. 52, No. 2, pp. 355-364, 2013. PMID: 23276288

            “Binding of Diverse Environmental Chemicals with Human Cytochromes P450 2A13, 2A6, and 1B1 and Enzyme Inhibition”, T. Shimada, D. Kim, N. Murayama, K. Tanaka, S. Takenaka, L.D. Nagy, L.M. Folkman, M.K. Foroozesh, M. Komori, H. Yamazaki, and F.P. Guengerich, Chemical Research in Toxicology, Vol. 26, pp. 517−528, 2013. PMID: 23432429

            "Pyranoflavones: A Group of Small-molecule Probes for Exploring the Active Site Cavities of Cytochrome P450 Enzymes 1A1, 1A2, and 1B1", J. Liu, S. Taylor, P. Dupart, C. Arnold, J. Sridhar, Q. Jiang, Y. Wang, M. Zhao, and M. Foroozesh, Journal of Medicinal Chemistry, Vol. 56, No. 10, pp. 4082–4092, 2013. PMID: 23600958, PMCID: PMC3685175.

           “A Review of Ceramide Analogs as Potential Anticancer Agents”, J. Liu, B.S. Beckman, and M. Foroozesh, Future Med Chem, Vol. 5, No. 12, pp. 1405-1421, 2013.

          “Cytochrome P450 Family 1 Inhibitors and Structure-Activity Relationship”, J. Liu, J. Sridhar, and M. Foroozesh, Molecules, Vol. 18, pp. 14470-14495, 2013.

“Design, Synthesis, and Evaluation of a Family of Propargyl Pyridinyl Ethers as Potential Cytochrome P450 Inhibitors”, M. Foroozesh, Q. Jiang, J. Sridhar, J. Liu, Minaruzzaman, B. Dotson, and E. McClain, Journal of Undergraduate Chemistry Research, Vol. 12, No. 4, pp. 92-95, 2013. 

“Design, and Synthesis of Carbazole Analogs As Potential Cytochrome P450 Inhibitors”, M. Foroozesh, Q. Jiang, J. Sridhar, J. Liu, B. Dotson, and E. McClain, Journal of Undergraduate Chemistry Research, Vol. 12, No. 4, pp. 89-91, 2013. 

“3-Ketone-4,6-diene Ceramide Analogs Exclusively Induce Apoptosis in Chemo-resistant Cancer Cells”, A. Ponnapakkam, J. Liu, B.A. Drew, T.L. Wang, J.W. Antoon, T.T. Nguyen, P.S. Dupart, M. Foroozesh, and B.S. Beckman, Bioorganic and Medicinal Chem., Vol. 22, No. 4, pp. 1412-1420, 2014.  PMCID: PMC3967587.

“Innovation Through Institutional Integration (I-Cubed) Program at Xavier University of Louisiana”, L. Blanchard, M. Foroozesh, T.S. Coston, And E.Y. Hammer, EDULearn Proceedings, International Academy of Technology, Education and Development (IATED) Digital Library, July 2014.

“Ethynylflavones, Highly Potent and Selective Inhibitors of Cytochrome P450 1A1”, N. Goyal, J. Liu, L. Lovings, P. Dupart, S. Taylor, S. Bellow, L. Mensah, E. McClain, B. Dotson, J. Sridhar, X. Zhang, M. Zhao, and M Foroozesh, Chemical Research in Toxicology, Vol. 27, No.8, pp. 1431–1439, 2014. PMID: 25033111, PMC4137986

“A Ligand-Based Drug Design, Discovery of 4-Trifluoromethyl-7,8-Pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2”, J. Liu, P. Pham, E. Skripnikova, S. Zheng, L. Lovings, Y. Wang, N. Goyal, S. Bellow, L. Mensah, A. Chatters, M. Bratton, T. Wiese, M. Zhao, G. Wang, and M. Foroozesh, Journal of Medicinal Chemistry, Vol. 58, No. 16, pp. 6481-6493, 2015.
“Oxidation of Pyrene, 1-Hydroxypyrene, 1-Nitropyrene, and 1-Acetylpyrene by Human Cytochrome P450 2A13”, T. Shimada, S. Takenaka, N. Murayama, V.M. Kramlinger, J.H. Kim, D. Kim, J. Liu, M.K. Foroozesh, H. Yamazaki, F.P. Guengerich, and M. Komori, Xenobiotica, Vol. 46, No. 3, pp. 211-224, 2016.

“Novel Functionalized 5-(Phenoxymethyl)-1,3-dioxane Analogs Exhibiting Cytochrome P450 Inhibition: A Patent Evaluation WO2015048311 (A1)”, R.L. Schroeder, P. Tram, J. Liu, M. Foroozesh, and J. Sridhar, Expert Opin Ther Pat., Vol. 26, No. 1, pp. 139-47, 2016.

“Structure−Function Studies of Naphthalene, Phenanthrene, Biphenyl, and Their Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6”, T. Shimada, S. Takenaka, K. Kakimoto, N. Murayama, Y-R. Lim, D. Kim, M.K. Foroozesh, H. Yamazaki, F.P. Guengerich, and M. Komori, Chemical Research in Toxicology, Vol. 29, No. 6, pp. 1029–1040, 2016.

“Ortho-Methylarylamines as Potential Mechanism-Based Inhibitors of Cytochrome P450 1A1 and 1A2 Enzymes", J. Sridhar, M. Foroozesh, J. Liu, Q. Jiang, K. Riley, R. Schroeder, N. Pham, and P. Tram, Drug Metabolism Letters, Vol. 10, No. 4, pp. 270-277, 2016.

            “Review of Ligand Specificity Factors for CYP1A Subfamily Enzymes from Molecular Modeling Studies Reported To-Date”, J. Sridhar, N. Goyal, J. Liu, and M. Foroozesh, Molecules, Vol. 22, No. 7, 1143, 2017.

            “Optimization of scale-up synthesis of anti-cancer ceramide Analog 315”, N. Goyal, T. Jackson, C. Do, S. Booker, T. Hill, J. Liu, and M. Foroozesh, submitted to the Journal of Undergraduate Chemistry Research, June 2017.

Department of Chemistry

504-520-5082