Jiawang Liu, Ph.D.

2008.05-Present:
Postdoctoral Fellow
Department of Chemistry
Xavier University of Louisiana
Advisor: DR. Maryam Foroozesh

1. Design and syntheses of ceramide analogs as potential treatment for chemo- and endocrine-resistant breast cancers
2. Syntheses and in vitro inhibition studies of potential cytochrome P450 inhibitors

Co-Principal Investigator
Proposal Title: Multi-Target, Mechanism-Based Drug Design for the Treatment of Breast Cancer: Synthesis, Screening, and Mechanism Investigation of a Ceramide Analog Library
Source of Support: NIH AREA
Period Covered:  March 1, 2011- Feb. 29, 2014 

Liu J.; Nguyen T.T.; Dupart P.; Sridhar J.; Zhang X.; Zhu N.; Stevens C.K.; Foroozesh M. ,7-Ethynylcoumarins: Selective Inhibitors of Human Cytochrome P450s 1A1 and 1A2, Chemical Research in Toxicology, Vol. 25, No. 5, pp. 1047-1057, 2012.
Sridhar J.; Liu J.; Foroozesh M.; Stevens C.K., Inhibition of Cytochrome P450 Enzymes by Quinones and Anthraquinones, Chemical Research in Toxicology, Vol. 25, No. 2, pp. 357-65, 2012.
Liu J.; Wang Y.; Yang Y.; Jiang X.; Zhao M.; Wang W.; Wu G.; Wu J.; Zheng M.; Peng S., Pyrolo[1,2:4,5]-1,4-dioxopyrazino[1,2:1,6] pyrido[3,4-b]indoles: A Group of Urokinase Inhibitors, their Synthesis, and Stereochemistry-Dependent Activity, ChemMedChem, 6, 2312-2322, 2011.
Liu J.; Antoon J.W.; Ponnapakkam A.; Beckman B.S.; Foroozesh M. ,Novel Anti-Proliferative Ceramide Analogs: Design, Synthesis, and Structure-Activity Relationship Studies of Substituted (S)-2-(Benzylideneamino)-3-hydroxy-N-tetradecylpropanamides, Bioorg. Med. Chem., 18, 5316-5322, 2010.
Antoon J.; Liu. J.; Ponnapakkam A.; Foroozesh M.; Beckman B.S., Novel D-Erythro N-Octanoyl Sphingosine Analogues as Chemo- and Endocrine Resistant Breast Cancer Therapeutics, Cancer Chemother. Pharmacol., 65, 1191-1195, 2010.
Sridhar J.; Jin P.; Liu J.; Foroozesh M.; Stevens C., In Silico Studies to Determine Structural Features Influencing Polyaromatic Hydrocarbon Inhibition Potency of Cytochrome P450 Enzymes 1A1, 1A2, 2A6 and 2B1, Chemical Research in Toxicology, 23, 600-607, 2010.
Zhu N.; Lightsey D.; Liu J.; Foroozesh M.; Morgan K.M.; Stevens E.D.; Stevens C.K., Ethynyl and Propynyl Pyrene Inhibitors of Cytochrome P450, J. Chem. Crystallogr., 40, 343-352, 2010.
Liu J.; Jiang X.; Zhao M.; Zhang X.; Zheng M.; Peng L.; Peng S., A Class of 3S-2-aminoacyltetrahydro-beta-carboline-3-carboxylic acids: their Facile Synthesis, Inhibition for Platelet Activation, and High in Vivo Anti-thrombotic Potency, J. Med. Chem., 53, 3106–3116, 2010.
Antoon J.; Liu J.; Gestaut M.; Burow M.; Beckman B.; Foroozesh M., Design, Synthesis, and Biological Activity of a Family of Novel Ceramide Analogues in Chemoresistant Breast Cancer Cells, J. Med. Chem., 52, 5748–5752, 2009.
Liu J.; Zhao M.; Cui G.; Zhang X.; Wang J.; Peng S., Methyl (11aS)-1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo-[3',4':1,2]pyridin[3,4-b]indol-2-substituted Acetates: Synthesis and Three-Dimensional Quantitative Structure-Activity Relationship Investigation as a Class of Novel Vasodilators, J. Med. Chem., 51, 4715-4723, 2008.
Liu J.; Cui G.; Zhao M.; Cui C.; Ju J.; Peng S., Dual-Acting Agents that Possess Reversing Resistance and Anticancer Activities: Design, Synthesis, MES-SA/Dx5 Cell Assay, and SAR of Benzyl 1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H- imidazo[3′,4′:1,2]pyridin [3,4-b]indol-2-substitutedacetates, Bioorg. Med. Chem., 15, 7773-7788, 2007.
Liu J.; Wu G., Cui G.; Wang W., Zhao M.; Wang C.; Zhang Z.; Peng S., A New Class of Anti-Thrombosis Hexahydropyrazino-[1’,2’:1,6]pyrido-[3,4-b]-indole-1,4-dions: Design, Synthesis, logK Determination and QSAR Analysis, Bioorg. Med. Chem., 15, 5672-5693, 2007.