DEPARTMENT OF CHEMISTRY
 

 
FACULTY/Staff PROFILE
seporator

Jiawang Liu, Ph.D.

Telephone Number: 504-520-6742
Room Number: NCF Annex - Room 372
Email Address: jliu1@xula.edu

 

Courses

 

 

Short Professional Biography

2008.05-Present:
Postdoctoral Fellow
Department of Chemistry
Xavier University of Louisiana
Advisor: DR. Maryam Foroozesh

2002.09-2007.07: 
Ph.D., Medicinal Chemistry,
Division of Medicinal Chemistry,
College of Pharmaceutical Sciences, 
Peking University, Beijing 100083, P R China.

1998.09-2002.07: 
B.S., College of Pharmaceutical Sciences,
Peking University, Beijing 100083, P R China.

 

Research Interest
  1. Design and syntheses of ceramide analogs as potential treatment for chemo- and endocrine-resistant breast cancers
  2. Syntheses and in vitro inhibition studies of potential cytochrome P450 inhibitors

 

Current Grant Support

Co-Investigator
Proposal Title: Multi-Target, Mechanism-Based Drug Design for the Treatment of Breast Cancer: Synthesis, Screening, and Mechanism Investigation of a Ceramide Analog Library
Source of Support: NIH AREA
Period Covered:  March 1, 2011- Feb. 29, 2014 

 

Recent Publications

1.             Goyal, N; Liu, J; Lovings, L; Dupart, P; Taylor, S; Bellow, S; Mensah, L; McClain, E; Dotson, B; Sridhar, J; Zhang, X; Zhao, M; Foroozesh, M., Ethynylflavones, highly potent and selective inhibitors of cytochrome P450 1A1. Chem Res Toxicol, Accepted, July 2014, PMID: 25033111.

2.             Shimada, T.; Takenaka, S.; Murayama, N.; Kramlinger, V. M.; Kim, J.; Kim, D.; Liu, J.; Foroozesh, M.; Yamazaki, H.; Guengerich, F. P.; Komori, M., Catalytic specificity of human cytochrome P450 2A13 in the oxidative metabolism of pyrene, 1-hydroxypyrene, 1-nitropyrene, and 1-acetylpyrene. Chem Res Toxicol, minor revision processing, 2014.

3.             Ponnapakam, A. P.; Liu, J.; Bhinge, K. N.; Drew, B. A.; Wang, T. L.; Antoon, J. W.; Nguyen, T. T.; Dupart, P. S.; Wang, Y.; Zhao, M.; Liu, Y. Y.; Foroozesh, M.; Beckman, B. S., 3-Ketone-4,6-diene ceramide analogs exclusively induce apoptosis in chemo-resistant cancer cells. Bioorg Med Chem2014, 22 (4), 1412-20.

4.             Liu, J.; Taylor, S. F.; Dupart, P. S.; Arnold, C. L.; Sridhar, J.; Jiang, Q.; Wang, Y.; Skripnikova, E. V.; Zhao, M.; Foroozesh, M., Pyranoflavones: A Group of Small-Molecule Probes for Exploring the Active Site Cavities of Cytochrome P450 Enzymes 1A1, 1A2, and 1B1. J Med Chem2013, 56 (10), 4082-92.

5.             Liu, J.; Sridhar, J.; Foroozesh, M., Cytochrome P450 family 1 inhibitors and structure-activity relationships. Molecules2013, 18 (12), 14470-95.

6.             Jin, S.; Wang, Y.; Zhu, H.; Zhao, S.; Zhao, M.; Liu, J.; Wu, J.; Gao, W.; Peng, S., Nanosized aspirin-Arg-Gly-Asp-Val: delivery of aspirin to thrombus by the target carrier Arg-Gly-Asp-Val tetrapeptide. ACS Nano 2013, 7 (9), 7664-73.

7.             Liu, J.; Beckman, B. S.; Foroozesh, M., A review of ceramide analogs as potential anticancer agents. Future Med Chem2013, 5 (12), 1405-21.

8.             Zhang, H.; Gay, S. C.; Shah, M.; Foroozesh, M.; Liu, J.; Osawa, Y.; Zhang, Q.; Stout, C. D.; Halpert, J. R.; Hollenberg, P. F., Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: implications for allosteric modulation of cytochrome P450 catalysis. Biochemistry2013, 52 (2), 355-64.

9.             Liu, J.; Nguyen, T. T.; Dupart, P. S.; Sridhar, J.; Zhang, X.; Zhu, N.; Stevens, C. L.; Foroozesh, M., 7-Ethynylcoumarins: selective inhibitors of human cytochrome P450s 1A1 and 1A2. Chem Res Toxicol2012, 25 (5), 1047-57.

10.          Sridhar, J.; Liu, J.; Foroozesh, M.; Klein Stevens, C. L., Inhibition of cytochrome p450 enzymes by quinones and anthraquinones. Chem Res Toxicol2012, 25 (2), 357-65.

11.          Li, L.; Wu, J.; Zhao, M.; Wang, Y.; Zhang, H.; Zhang, X.; Gui, L.; Liu, J.; Mair, N.; Peng, S., Poly-α,β-DL-aspartyl-L-cysteine: a novel nanomaterial having a porous structure, special complexation capability for Pb(II), and selectivity of removing Pb(II). Chem Res Toxicol2012, 25 (9), 1948-54.

12.          Sridhar, J.; Liu, J.; Foroozesh, M.; Stevens, C. L., Insights on cytochrome p450 enzymes and inhibitors obtained through QSAR studies. Molecules 2012, 17 (8), 9283-305.

13.          Sridhar, J.; Ellis, J.; Dupart, P.; Liu, J.; Stevens, C. L.; Foroozesh, M., Development of Flavone Propargyl Ethers as Potent and Selective Inhibitors of Cytochrome P450 Enzymes 1A1 and 1A2. Drug Metab Lett 2012, 6 (4), 275-84.

 

14.          Yang, G.; Zhu, H.; Zhao, M.; Wu, J.; Wang, Y.; Zheng, M.; Chen, M.; Liu, J.; Peng, S., The application of tetrahydroisoquinoline-3-carbonyl-TARGD(F)F as an anti-thrombotic agent having dual mechanisms of action. Mol Biosyst2012, 8 (10), 2672-9.

15.          Wang, Y.; Kang, G.; Liu, J.; Zhao, M.; Wu, J.; Zhang, X.; Li, Y.; Zhong, X.; Yang, Y.; Peng, S., Novel potassium N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxylhex-1-yl]-L-amino acid dichloroplatinates(II) with high anti-tumor activity and low side reaction. Metallomics2012, 4 (5), 441-7.

16.          Zhang, H.; Wang, Y.; Zhao, M.; Wu, J.; Zhang, X.; Gui, L.; Zheng, M.; Li, L.; Liu, J.; Peng, S., Synthesis and in vivo lead detoxification evaluation of Poly-α,β-dl-aspartyl-l-methionine. Chem Res Toxicol2012, 25 (2), 471-7.

17.          Liu, J.; Wang, Y.; Yang, Y.; Jiang, X.; Zhao, M.; Wang, W.; Wu, G.; Wu, J.; Zheng, M.; Peng, S., Pyrolo[1,2:4,5]-1,4-dioxopyrazino[1,2:1,6]pyrido[3,4-b]indoles: a group of urokinase inhibitors, their synthesis, and stereochemistry-dependent activity. ChemMedChem2011, 6 (12), 2312-22.

18.          Mei, S.; Liu, J.; Zhao, M.; Wang, W.; Wang, Y.; Wu, G.; Zheng, M.; Peng, S., From Cerius² based stereoview to mouse and enzyme: the model systems for discovery of novel urokinase inhibitors. Mol Biosyst 2011, 7 (9), 2664-9.

19.          Wang, Y.; Kang, G.; Zhao, M.; Wu, J.; Zhang, X.; Yang, Y.; Liu, J.; Peng, S., A new platinum-complex showing easy preparation, promising anti-tumor activity, and better efficacy and distribution properties than oxaliplatin. Mol Biosyst2011, 7 (12), 3245-52.

20.          Li, C.; Zhang, X.; Zhao, M.; Wang, Y.; Wu, J.; Liu, J.; Zheng, M.; Peng, S., A class of novel N-(1-methyl-β-carboline-3-carbonyl)-N'-(aminoacid-acyl)-hydrazines: aromatization leaded design, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis. Eur J Med Chem2011, 46 (11), 5598-608.

21.          Wang, Y.; Jiang, X.; Liu, J.; Zhao, M.; Kang, G.; Wu, J.; Peng, L.; Peng, S., HPLC-MS aided PC12 cell systems: to quantitatively monitor the conversion of nitronyl nitroxide in biological systems with and without NO. Mol Biosyst2011, 7 (5), 1678-83.

22.          Wang, H.; Peng, L.; Zhao, M.; Liu, J.; Zhang, X.; Wang, Y.; Wu, J.; Li, L.; Peng, S., 2-Substituted (S)-2-(3,3-dimethyl-1-oxo-10,10a-dihydroimidazo[1,5-b]isoquinolin-2(1H,3H,5H)-yl)acetic acids: Conformational prediction, synthesis, anti-thrombotic and vasodilative evaluation. Bioorg Med Chem2011, 19 (2), 871-82.

23.          Wang, W.; Zhao, M.; Wang, Y.; Liu, J.; Wu, J.; Kang, G.; Peng, S., {2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic acid methyl ester (MIAM): its anti-cancer efficacy and intercalation mechanism identified via multi-model systems. Mol Biosyst2011, 7 (3), 766-72.

24.          Liu, J.; Jiang, X.; Zhao, M.; Zhang, X.; Zheng, M.; Peng, L.; Peng, S., A class of 3S-2-aminoacyltetrahydro-beta-carboline-3-carboxylic acids: their facile synthesis, inhibition for platelet activation, and high in vivo anti-thrombotic potency. J Med Chem 2010, 53 (8), 3106-16.

25.          Liu, J.; Antoon, J. W.; Ponnapakkam, A.; Beckman, B. S.; Foroozesh, M., Novel anti-viability ceramide analogs: design, synthesis, and structure-activity relationship studies of substituted (S)-2-(benzylideneamino)-3-hydroxy-N-tetradecylpropanamides. Bioorg Med Chem2010, 18 (14), 5316-22.

26.          Liu, J.; Zhao, M.; Qian, K.; Zhang, X.; Lee, K. H.; Wu, J.; Liu, Y. N.; Peng, S., Benzyl 1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo[3',4':1,2]pyridin[3,4-b]indole-2-substituted acetates: One-pot-preparation, anti-tumor activity, docking toward DNA and 3D QSAR analysis. Bioorg Med Chem2010, 18 (5), 1910-7.

27.          Sridhar, J.; Jin, P.; Liu, J.; Foroozesh, M.; Stevens, C. L., In silico studies of polyaromatic hydrocarbon inhibitors of cytochrome P450 enzymes 1A1, 1A2, 2A6, and 2B1. Chem Res Toxicol2010, 23 (3), 600-7.

28.          Zhao, M.; Wang, Y.; Huo, C.; Liu, J.; Li, C.; Zhang, X.; Peng, L.; Peng, S., Lead detoxification activity and ADMET hepatotoxicity of N-(alpha-L-arabino-furanos-1-yl)-L-cysteine. Chem Res Toxicol2010, 23 (7), 1282-5.

29.          Antoon, J. W.; Liu, J.; Ponnapakkam, A. P.; Gestaut, M. M.; Foroozesh, M.; Beckman, B. S., Novel D: -erythro N-octanoyl sphingosine analogs as chemo- and endocrine-resistant breast cancer therapeutics. Cancer Chemother Pharmacol2010, 65 (6), 1191-5.

30.          Zhu, N.; Lightsey, D.; Liu, J.; Foroozesh, M.; Morgan, K. M.; Stevens, E. D.; Klein Stevens, C. L., Ethynyl and Propynylpyrene Inhibitors of Cytochrome P450. J Chem Crystallogr2010, 40 (4), 343-352.

31.          Antoon, J. W.; Liu, J.; Gestaut, M. M.; Burow, M. E.; Beckman, B. S.; Foroozesh, M., Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells. J Med Chem2009, 52 (18), 5748-52.

32.          Liu, J.; Zhao, M.; Cui, G.; Zhang, X.; Wang, J.; Peng, S., Methyl (11aS)-1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo-[3',4':1,2]pyridin[3,4-b]indol-2-substituted acetates: synthesis and three-dimensional quantitative structure-activity relationship investigation as a class of novel vasodilators. J Med Chem 2008, 51 (15), 4715-23.

33.          Liu, J.; Wu, G.; Cui, G.; Wang, W. X.; Zhao, M.; Wang, C.; Zhang, Z.; Peng, S., A new class of anti-thrombosis hexahydropyrazino-[1',2':1,6]pyrido-[3,4-b]-indole-1,4-dions: design, synthesis, logK determination, and QSAR analysis. Bioorg Med Chem2007, 15 (17), 5672-93.

34.          Liu, J.; Cui, G.; Zhao, M.; Cui, C.; Ju, J.; Peng, S., Dual-acting agents that possess reversing resistance and anticancer activities: Design, synthesis, MES-SA/Dx5 cell assay, and SAR of Benzyl 1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo[3',4':1,2]pyridin[3,4-b]indol-2-substitutedacetates. Bioorg Med Chem2007, 15 (24), 7773-88.

35.          Wu, G.; Liu, J.; Bi, L.; Zhao, M.; Wang, C.; Baudy-Floc'h, M.; Ju, J.; Peng, S., Toward breast cancer resistance protein (BCRP) inhibitors: design, synthesis of a series of new simplified fumitremorgin C analogues. Tetrahedron 2007, 63 (25), 5510-28.

 

 
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