Jiawang Liu, Ph.D.

2008.05-Present:
Postdoctoral Fellow
Department of Chemistry
Xavier University of Louisiana
Advisor: DR. Maryam Foroozesh

1. Design and syntheses of ceramide analogs as potential treatment for chemo- and endocrine-resistant breast cancers
2. Syntheses and in vitro inhibition studies of potential cytochrome P450 inhibitors

Co-Principal Investigator
Proposal Title: Multi-Target, Mechanism-Based Drug Design for the Treatment of Breast Cancer: Synthesis, Screening, and Mechanism Investigation of a Ceramide Analog Library
Source of Support: NIH AREA
Period Covered:  March 1, 2011- Feb. 29, 2014 

Liu J.; Nguyen T.T.; Dupart P.; Sridhar J.; Zhang X.; Zhu N.; Stevens C.K.; Foroozesh M. 7-Ethynylcoumarins: Selective Inhibitors of Human Cytochrome P450s 1A1 and 1A2, submitted to Chem. Res. Toxicol., January 2012.
Sridhar J.; Liu J.; Foroozesh M.; Stevens C.K. Inhibition of Cytochrome P450 Enzymes by Quinones and Anthraquinones. Chem. Res. Toxicol. 2011 Dec 20. DOI: 10.1021/tx2004163.

Liu J.; Wang Y.; Yang Y.; Jiang X.; Zhao M.; Wang W.; Wu G.; Wu J.; Zheng M.; Peng S. Pyrolo[1,2:4,5]-1,4-dioxopyrazino[1,2:1,6]pyrido[3,4-b]indoles: A Group of Urokinase Inhibitors, their Synthesis, and Stereochemistry-Dependent Activity. ChemMedChem 2011, 6, 2312-2322.

Liu J.; Antoon J.W.; Ponnapakkam A.; Beckman B.S.; Foroozesh M. Novel Anti-Proliferative Ceramide Analogs: Design, Synthesis, and Structure-Activity Relationship Studies of Substituted (S)-2-(Benzylideneamino)-3-hydroxy-N-tetradecylpropanamides. Bioorg. Med. Chem. 2010, 18, 5316-5322.

Antoon J.; Liu. J.; Ponnapakkam A.; Foroozesh M.; Beckman B.S. Novel D-erythro N-Octanoyl Sphingosine Analogues as Chemo- and Endocrine Resistant Breast Cancer Therapeutics. Cancer Chemother. Pharmacol.  2010, 65, 1191-1195.

Sridhar J.; Jin P.; Liu J.; Foroozesh M.; Stevens C. In Silico Studies to Determine Structural Features Influencing Polyaromatic Hydrocarbon Inhibition Potency of Cytochrome P450 enzymes 1A1, 1A2, 2A6 and 2B1. Chem. Res. Toxicol. 2010, 23, 600-607.

Zhu N.; Lightsey D.; Liu J.; Foroozesh M.; Morgan K.M.; Stevens E.D.; Stevens C.K. Ethynyl and Propynyl Pyrene Inhibitors of Cytochrome P450. J. Chem. Crystallogr. 2010, 40, 343-352.

Liu J.; Jiang X.; Zhao M.; Zhang X.; Zheng M.; Peng L.; Peng S. A class of 3S-2-aminoacyltetrahydro-beta-carboline-3-carboxylic acids: their facile synthesis, inhibition for platelet activation, and high in vivo anti-thrombotic potency. J. Med. Chem. 2010, 53, 3106–3116.

Antoon J.; Liu J.; Gestaut M.; Burow M.; Beckman B.; Foroozesh M. Design, Synthesis, and Biological Activity of a Family of Novel Ceramide Analogues in Chemoresistant Breast Cancer Cells. J. Med. Chem. 2009, 52, 5748–5752.

Liu J.; Zhao M.; Cui G.; Zhang X.; Wang J.; Peng S. Methyl (11aS)-1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo-[3',4':1,2]pyridin[3,4-b]indol-2-substituted acetates: synthesis and three-dimensional quantitative structure-activity relationship investigation as a class of novel vasodilators. J. Med. Chem. 2008, 51, 4715-4723.

Liu J.; Cui G.; Zhao M.; Cui C.; Ju J.; Peng S. Dual-acting agents that possess reversing resistance and anticancer activities: Design, synthesis, MES-SA/Dx5 cell assay, and SAR of Benzyl 1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H- imidazo[3′,4′:1,2]pyridin[3,4-b]indol-2-substitutedacetates. Bioorg. Med. Chem. 2007, 15, 7773-7788.

Liu J.; Wu G., Cui G.; Wang W., Zhao M.; Wang C.; Zhang Z.; Peng S. A new class of anti-thrombosis hexahydropyrazino-[1’,2’:1,6]pyrido-[3,4-b]-indole-1,4-dions: Design, synthesis, logK determination and QSAR analysis. Bioorg. Med. Chem. 2007, 15, 5672-5693.