Jiawang Liu, Ph.D.

Telephone Number: 504-520-6742
Room Number: NCF Annex - Room 372
Email Address:





Short Professional Biography

Postdoctoral Fellow
Department of Chemistry
Xavier University of Louisiana
Advisor: DR. Maryam Foroozesh

Ph.D., Medicinal Chemistry,
Division of Medicinal Chemistry,
College of Pharmaceutical Sciences, 
Peking University, Beijing 100083, P R China.

B.S., College of Pharmaceutical Sciences,
Peking University, Beijing 100083, P R China.


Research Interest
  1. Design and syntheses of ceramide analogs as potential treatment for chemo- and endocrine-resistant breast cancers
  2. Syntheses and in vitro inhibition studies of potential cytochrome P450 inhibitors


Current Grant Support

Proposal Title: Multi-Target, Mechanism-Based Drug Design for the Treatment of Breast Cancer: Synthesis, Screening, and Mechanism Investigation of a Ceramide Analog Library
Source of Support: NIH AREA
Period Covered:  March 1, 2011- Feb. 29, 2014 


Recent Publications

1.            Liu J, Beckman BS, Foroozesh M. A review of ceramide analogs as potential anticancer agents. Future Med Chem. 2013;5(12):1405-1421.

2.            Liu J, Taylor SF, Dupart PS, et al. Pyranoflavones: A Group of Small-Molecule Probes for Exploring the Active Site Cavities of Cytochrome P450 Enzymes 1A1, 1A2, and 1B1. J Med Chem. 2013;56(10):4082-4092.

3.            Sridhar J, Ellis J, Dupart P, Liu J, Stevens CL, Foroozesh M. Development of Flavone Propargyl Ethers as Potent and Selective Inhibitors of Cytochrome P450 Enzymes 1A1 and 1A2. Drug Metab Lett. 2012;6(4):275-284.

4.            Sridhar J, Liu J, Foroozesh M, Stevens CL. Insights on cytochrome p450 enzymes and inhibitors obtained through QSAR studies. Molecules. 2012;17(8):9283-9305.

5.           Liu J, Nguyen TT, Dupart PS, et al. 7-Ethynylcoumarins: selective inhibitors of human cytochrome P450s 1A1 and 1A2. Chem Res Toxicol. 2012;25(5):1047-1057.

6.            Sridhar J, Liu J, Foroozesh M, Klein Stevens CL. Inhibition of cytochrome p450 enzymes by quinones and anthraquinones. Chem Res Toxicol. 2012;25(2):357-365.

7.            Liu J, Wang Y, Yang Y, et al. Pyrolo[1,2:4,5]-1,4-dioxopyrazino[1,2:1,6]pyrido[3,4-b]indoles: a group of urokinase inhibitors, their synthesis, and stereochemistry-dependent activity. ChemMedChem. 2011;6(12):2312-2322.

8.            Liu J, Antoon JW, Ponnapakkam A, Beckman BS, Foroozesh M. Novel anti-viability ceramide analogs: design, synthesis, and structure-activity relationship studies of substituted (S)-2-(benzylideneamino)-3-hydroxy-N-tetradecylpropanamides. Bioorg Med Chem. 2010;18(14):5316-5322.

9.            Liu J, Jiang X, Zhao M, et al. A class of 3S-2-aminoacyltetrahydro-beta-carboline-3-carboxylic acids: their facile synthesis, inhibition for platelet activation, and high in vivo anti-thrombotic potency. J Med Chem. 2010;53(8):3106-3116.

10.          Antoon JW, Liu J, Ponnapakkam AP, Gestaut MM, Foroozesh M, Beckman BS. Novel D: -erythro N-octanoyl sphingosine analogs as chemo- and endocrine-resistant breast cancer therapeutics. Cancer Chemother Pharmacol. 2010;65(6):1191-1195.

11.          Antoon JW, Liu J, Gestaut MM, Burow ME, Beckman BS, Foroozesh M. Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells. J Med Chem. 2009;52(18):5748-5752.

12.          Liu J, Zhao M, Cui G, Zhang X, Wang J, Peng S. Methyl (11aS)-1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo-[3',4':1,2]pyridin[3,4-b]indol-2-substituted acetates: synthesis and three-dimensional quantitative structure-activity relationship investigation as a class of novel vasodilators. J Med Chem. 2008;51(15):4715-4723.


Campus Map        Directory         Contact Us         EMERGENCY PREPAREDNESS    © Xavier University of Louisiana. All rights reserved.
(504) 486-7411
EST 1925