Guangdi Wang, Ph.D.
Professor of Chemistry

Telephone Number: 504-520-5076
Room Number: NCF Annex - Room 339
Email Address:



General Chemistry Lab (Chem1021 L)
Quantitative Analysis lecture (Chem3210)
Quantitative Analysis lab (Chem3210L)
Instrumental Analysis (Chem4240 w/L)


Short Professional Biography

Dr. Guangdi Wang is Professor of Chemistry in the Department of Chemistry, Xavier University of Louisiana. He also holds adjunct faculty positions at Tulane University and the University of New Orleans where he collaborates with Professors Roy Weiner, John McLachlan, Matthew Burow, Hua Lu on research involving cancer proteomics and therapeutic development for cancer treatment. Dr. Wang holds a Ph.D. in Analytical Chemistry from the University of New Orleans. His graduate research focused on the fundamental aspects of mass spectrometry, which gave him extensive experience in sophisticated mass spectrometric techniques and their biomedical applications.


Research Interest

Dr. Guangdi Wang’s research focuses on: 1. Design, synthesis, and biological evaluation of selective estrogen receptor modulators for breast cancer, anti-metastasis and vascular disrupting agents for cancer therapeutic development; 2. Proteomics for target and biomarker identication in cancer; 3. Environmental studies that track the pollution levels of endocrine disruptors and carcinogens.


Current Grant Support

2G12MD007595                                             8/1/2009 – 7/31/2019    
Xavier’s RCMI Cancer Research Center                                        
The goals of Xavier’s RCMI program are to enhance university-wide cancer research infrastructure and faculty research competitiveness by establishing core laboratories and supporting pilot projects.
Role: Program Director
Louisiana Cancer Research Consortium         7/1/2013 – 6/30/2014
Novel Thiazole Inhibitors of Fascin as Anti-metastasis Therapeutics                                   
The goal of the proposed research is to determine the mechanism of thiazole action in inhibiting cancer cell migration and invasion in vitro, and tumor metastasis in vivo..
Role: PI

Louisiana Clinical and Translational Science Center Pilot Project (LACaTS)
1/23/2014 – 1/22/2015             
Boron-based 4-Hydroxytamoxifen and Endoxifen Prodrugs for Treatment of Breast Cancer

The goal of this pilot project is to conduct preclinical studies of boron-4OHT and boron-endoxifen to determine the in vivo efficacy and pharmacokinetics.


Recent Publications
  1. Zheng S, Zhong Q, He L, Mottamal M, Sridhar J, Zhang Q, Wang G. Modification and Biological Evaluation of Thiazole Derivatives as Novel Inhibitors of Metastatic Cancer Cell Migration and Invasion, Journal of Medicinal Chemistry, 2014, July 9. [Epub ahead of print] PubMed PMID: 25007006.
  2. Zheng S, Zhong Q, Mottamal M, McFerrin H, Zhang Q, Wang G. Design, Synthesis, and Biological Evaluation of Novel Pyridine-Bridged Analogs of Combretastatin-A4 as Anti-cancer Agents, Journal of Medicinal Chemistry, 2014, 57(8):3369-81. doi: 10.1021/ jm500002k. Epub 2014 Apr 7. PubMed PMID: 24669888; PMCID: PMC4002123.
  3. Strong AL, Ohlstein J, Shi Z, Jiang Q, Zhang Q, Zheng S, Boue SM, Elliott S, Gimble JM, Burow ME, Wang G, Bunnell BA. Novel daidzein analogs enhance osteogenic activity of BMSCs and ASCs through estrogen dependent and independent mechanisms, Stem Cell Research and Therapy, 2014, in press.
  4. Samaan N, Zhong Q, Fernandez J, Chen G, Hussain AM, Zheng S, Wang G, Chen Q. Design, synthesis, and evaluation of novel heteroaromatic analogs of curcumin as anti-cancer agents, European Journal of Medicinal Chemistry, 2014, 75, 123-131.
  5. Zheng S, Wang G. Advances in developing estrogen receptor-targeting therapeutics for Tamoxifen-resistant breast cancer, in Medicinal chemistry advances: overcoming multidrug resistance in oncology, Future Medicine series, 2014, accepted.
  6. Scarritt ME, Bonvillain RW, Burkett BJ, Glotser, Zhang Q, Wang G, Betancourt AM, Sullivan DE, Bunnell BA, Hypertensive Rat Lungs Retain Hallmarks of Vascular Disease Upon Decellularization but Support the Growth of Mesenchymal Stem Cells, Tissue Engineering Part A, 2014, 20(9-10):1426-43..
  7. Tian Y, Wang L, Gillespie C, Wang G, Guo S. Leptin induces mammary cancer stem cells through STAT3/VEGFR-2/Notch signaling pathways, PLOS One, 2014, in revision.
  8. Stong A, Jiang Q, Zhang Q, Zheng S, Boue S, Elliott S, Burow ME, Bunnell BA, Wang G. Design, synthesis, and osteogenic activity of daidzein analogs on human mesenchymal stem cells, ACS Med Chem Lett, 2014, 5 (2), 143–148, Publication Date (Web): December 10, 2013.
  9. Zhou W, Wang G, Guo S. Regulation of angiogenesis via Notch signaling in breast cancer and cancer stem cells. BBA Review on Cancer, 2013, Dec; 1836(2): 304-20. doi: 10.1016/j.bbcan.2013.10.003. Epub 2013 Oct 30.
  10. Guo S, Yang L, Wang G, Asea AAA. Glutathione peroxidases in stem, cancer, and cancer stem cells. In Peroxidases: Biochemical Characteristics, Functions, and Potential Applications, Bogaert L and Coppens N Eds. ISBN: 978-1-62808-261-6, 2013.
  11. Kode NR, Vanden Eynde JJ, Mayence A, Wang G, Huang TL.  Design and Synthesis of N1, N5-bis [4-(5-Alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as potential antifungal prodrugs.  Molecules, 2013, 18(9):11250-11263.
  12. Guo S, Zou J, Wang G. Advances in the proteomic discovery of novel therapeutic targets in cancer, Drug Design, Development and Therapy, 2013, 7, 1259–1271.
  13. Jiang Q, Zheng S, Wang G. Development of new therapeutic agents for the treatment of tamoxifen-resistant breast cancer, Future Medicinal Chemistry, 2013, 5(9): 1023-1035.
  14. Tilghman S, Townley I, Zhong Q, Carriere P, Zou J, Llopis S, Preyan LC, Williams CC, Skripnikova E, Zhang Q, Wang G. Proteomic signatures of acquired letrozole resistance in breast cancer: suppressed estrogen signaling and increased cell motility and invasiveness, Molecular and Cellular Proteomics, 2013, 12(9):2440-2455.
  15. Zheng S, Zhong Q, Jiang Q, Mottamal M, Zhang Q, Zhu N, Burow ME, Worthylake RA, Wang G, Discovery of a series of thiazole derivatives as novel inhibitors of metastatic cancer cell migration and invasion, ACS Medicinal Chemistry Letters, 2013, 4, 191-196.
  16. Antoon JW, Lai R, Salvo V, Tang Y, Nitzchke AM, Martin EC, Elliott S, Nam SY, Xiong W, Rhodes LV, Collins-Burow B, David O, Wang G, Beckman BS, Nephew KP, Burow ME, MEK5/Erk5 Signaling Suppresses Estrogen Receptor Expression and Promotes Hormone-Independent Tumorigenesis, Plos One, 2013, 8(8): e69291. doi:10.1371/journal.pone.0069291
  17. Patel A, Townley I, Wang G, Singh M, Efficacy of Aerosolized Celecoxib Encapsulated Nanostructured Lipid Carrier in Non-small Cell Lung Cancer in Combination with Docetaxel, Pharmaceutical Research, 2013, May;30(5):1435-46.
  18. Rider MA, Zou J, Vanlandingham D, Nuckois J, Higgs S, Zhang Q, Lacey M, Kim J, Wang G, Hong YS, Quantitative proteomic analysis of the Anopheles gambiae(Diptera: Culicidae) midgut infected with o'nyong-nyong virus., J Med Entomol, 2013, Sep;50(5):1077-88. PubMed PMID: 24180113
  19. Guo S, Liu M, Wang G, Yang L, Gonzalez-Perez RR, Regulation of Angiogenesis via Notch Signaling in Human Malignancy, in Tumor Angiogenesis Regulators, in Tumor Angiogenesis Regulators.  Gonzalez-Perez R and Rueda BR ed. May 2013, CRC Press. pp. 37-90.
  20. Major D, Zhang Q, Wang G, Wang H. Oil-dispersant mixtures: understanding chemical composition and its relation to human toxicity, Toxicol and Environ Chem, 2012, Epub Sept 24, 2012.
  21. Liu M, Wang G, Gomez-Fernandez CR, Guo S. GREB1 functions as a growth promoter and is modulated by IL6/STAT3 in breast cancer, Plos One, 2012, 7(10):e46410. Epub 2012 Oct 3. PubMed PMID: 23056300.
  22. Jiang Q, Zhong Q, Zhang Q, Zheng S, Wang G, Boron-based 4-hydroxytamoxifen bioisosteres for treatment of de novo tamoxifen resistance in breast cancer, ACS Medicinal Chemistry Letters, 2012, 3 (5), 392–396.
  23. Abbaraju NV, Boutaghou MN, Townley I, Zhang Q, Wang G, Cole RB, Rees BB, Analysis of tissue proteomes of the Gulf killifish, Fundulus grandis Analysis of killifish tissue proteomes by 2D electrophoresis and MALDI-TOF/TOF mass spectrometry, Integrative and Comparative Biology 2012, 52(5): 626-35.
  24. Bonvillain RW, Danchuk S, Sullivan DE, Betancourt AM, Semon JA, Eagle ME, Mayeux JP,  Gregory AN, Wang G, Townley I, Borg Z, Weiss DJ, Bunnell BA,  A non-human primate model of lung regeneration:detergent-mediated decellularization and recellularization with mesenchymal stem cells, Tissue Engineering Part A, 2012, 18(23-24):2437-52.
  25. Rhodes LV, Tilghman SL, Boue SM, Wang S, Khalili H, Muir SE, Bratton MB, Zhang Q, Wang G, Burow ME, Collins-Burow BM, Glyceollins as novel targeted therapeutic for the treatment of metastatic triple-negative breast cancer, Oncology Lett. 2012, 3, 163-171.
  26. Zhou C, Zhong Q, Rhodes L, Townley I, Bratton MR, Zhang Q, Martin E, Elliott S, Collins-Burow BM, Burow ME, Wang G. Proteomic analysis of acquired tamoxifen resistance in MCF-7 cells reveals expression signatures associated with enhanced migration. Breast Cancer Research, 2012, Mar 14; 14(2): R45.   PMCID:PMC3446379
  27. Guo S, Liu M, Wang G, Torroella-Kouri M, Gonzalez-Perez RR. Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells. BBA Review on Cancer. 2012 Jan 24. 1825(2):207-222. PubMed PMID: 22289780.
  28. Wang G, Ma P, Zhang Q, Lewis J, Lacey M, Furukawa Y, O'Reilly SE, Meaux S, McLachlan J, Zhang S. Endocrine disrupting chemicals in New Orleans surface waters and Mississippi Sound sediments. J Environ Monit. 2012 May 2; 14(5):1353-64. Epub 2012 Mar 22. PubMed Central PMCID: PMC3345074.
  29. Acharya L, Judeh T, Wang G,  Zhu D, Optimal Signaling Pathway Structural Inference from Unordered and Overlapping Gene Sets, Bioinformatics, 2012 Feb 15;28(4):546-556. Epub 2011 Dec 22. PMCID: PMC3278757.


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