Guangdi Wang, Ph.D.
Professor of Chemistry

Quantitative Analysis Lecture and Lab, Instrumental Analysis Lecture and Lab, General Chemistry Lab

Dr. Guangdi Wang is Professor of Chemistry in the Department of Chemistry, Xavier University of Louisiana. He also holds adjunct faculty positions at Tulane University and the University of New Orleans where he collaborates with Professors John McLachlan, Matthew Burow, and Richard Cole on research involving proteomic analyses of breast cancer cells and fibroid cells. Dr. Wang holds a Ph.D. in Analytical Chemistry from the University of New Orleans. His graduate research focused on the fundamental aspects of mass spectrometry, which gave him extensive experience in sophisticated mass spectrometric techniques and their biomedical applications.

Dr. Guangdi Wang’s research focuses on: 1. Design, synthesis, and biological evaluation of selective estrogen receptor modulators for breast cancer, anti-metastasis and vascular disrupting agents for cancer therapeutic development; 2. Proteomics for target and biomarker identication in cancer; 3. Environmental studies that track the pollution levels of endocrine disruptors and carcinogens.

N00014-06-1-1136                                         10/1/2006 – 9/30/2012
Office of Naval Research
“Contaminant Profiling of Marine/Estuary Sediments”
The goal of this project is to characterize the contaminant profile of marine sediments in the Gulf of Mexico by collecting and analyzing sediment samples for contamination by four major groups of POPs including 17 PAHs, 28 PCBs, 29 organochlorines, and 12 pharmaceutically active compounds.
Role: PI

59-6435-8-317                                                7/1/2008 – 9/30/2012
USDA                                                                        
Design and Synthesis of Isoflavone and Glyceollin Derivatives as Potential Antagonists for the Estrogen Receptor
The goal of the proposed research is to design, synthesize, and evaluate biological activities of various phytoestrogen analogues. The long term goal is to find potent estrogen receptor antagonists that have anti-estrogen and anti-proliferation properties against breast cancer.
Role: PI

1G12RR026250-01                                        8/1/2009 – 7/31/2014             
NIH-NCRR                                                               
Xavier’s RCMI Cancer Research Program                                        
The goals of Xavier’s RCMI program are to enhance university-wide cancer research infrastructure and faculty research competitiveness by establishing core laboratories and supporting pilot projects.
Role: Program Director

Louisiana Cancer Research Consortium         7/1/2011 – 6/30/2013
Proteomics to Identify Novel Therapeutic Targets in Hormone Resistant Breast Cancer
The goal of this project is to identify and validate molecular targets involved in the acquired hormone resistance in breast cancer using a quantitative proteomics approach.
Role: PI

1. Liu M, Wang G, Gomez-Fernandez CR, Guo S. GREB1 functions as a growth promoter and is modulated by IL6/STAT3 in breast cancer, Plos One, 2012, in press.
2. Jiang Q, Zhong Q, Zhang Q, Zheng S, Wang G, Boron-based 4-hydroxytamoxifen bioisosteres for treatment of de novo tamoxifen resistance in breast cancer, ACS Medicinal Chemistry Letters, 2012, 3 (5), 392–396.
3. Abbaraju NV, Boutaghou MN, Townley I, Zhang Q, Wang G, Cole RB, Rees BB, Analysis of tissue proteomes of the Gulf killifish, Fundulus grandis Analysis of killifish tissue proteomes by 2D electrophoresis and MALDI-TOF/TOF mass spectrometry, Integrative and Comparative Biology 2012, May 31. [Epub ahead of print] PubMed PMID: 22537935.
4. Bonvillain RW, Danchuk S, Sullivan DE, Betancourt AM, Semon JA, Eagle ME, Mayeux JP,  Gregory AN, Wang G, Townley I, Borg Z, Weiss DJ, Bunnell BA,  A non-human primate model of lung regeneration:detergent-mediated decellularization and recellularization with mesenchymal stem cells, Tissue Engineering Part A, 2012, Jul 6. [Epub ahead of print] PubMed PMID: 22764775
5. Rhodes LV, Tilghman SL, Boue SM, Wang S, Khalili H, Muir SE, Bratton MB, Zhang Q, Wang G, Burow ME, Collins-Burow BM, Glyceollins as novel targeted therapeutic for the treatment of metastatic triple-negative breast cancer, Oncology Lett. 2012, 3, 163-171.
6. Zhou C, Zhong Q, Rhodes L, Townley I, Bratton MR, Zhang Q, Martin E, Elliott S, Collins-Burow BM, Burow ME, Wang G. Proteomic analysis of acquired tamoxifen resistance in MCF-7 cells reveals expression signatures associated with enhanced migration. Breast Cancer Research, 2012, Mar 14; 14(2): R45. PMID: 22417809.
7. Guo S, Liu M, Wang G, Torroella-Kouri M, Gonzalez-Perez RR. Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells. BBA Review on Cancer. 2012 Jan 24. 1825(2):207-222. PubMed PMID: 22289780.
8. Wang G, Ma P, Zhang Q, Lewis J, Lacey M, Furukawa Y, O'Reilly SE, Meaux S, McLachlan J, Zhang S. Endocrine disrupting chemicals in New Orleans surface waters and Mississippi Sound sediments. J Environ Monit. 2012 May 2;14(5):1353-64. Epub 2012 Mar 22. PubMed Central PMCID: PMC3345074.
9. Acharya L, Judeh T, Wang G,  Zhu D, Optimal Signaling Pathway Structural Inference from Unordered and Overlapping Gene Sets, Bioinformatics, 2012 Feb 15;28(4):546-556. Epub 2011 Dec 22. PMCID: PMC3278757
10. Zhang Q, Ma P, Cole RB, Wang G, In vitro metabolism of Indomethacin Morpholinylamide (BML-190), an Inverse Agonist for the Peripheral Cannabinoid Receptor (CB2) in Rat Liver Microsomes, European Journal of Pharmaceutical Sciences, 2010, 41(1):163-172.
11. Jiang Q, Payton-Stewart P, Elliott S, Driver J, Zhang Q, Zheng S, Bhatnagar D, Boue S, Sridhar J, Stevens C, McLachlin JA, Wiese TE, Burow ME, Wang G, Effects of 7-O Substitutions on Estrogenic and Antiestrogenic Activities of Daidzein Analogues in MCF-7 Breast Cancer Cells, Journal of Medicinal Chemistry, 2010, 53 (16): 6153–6163.  PMCID: PMC2956131. 

12. Zhou C, Xiong W, Zhang Q, Tang Y, Bloch M, Weldon CB,  Elliott S, McLachlan JA, Barbara S. Beckman BS, Wiese TE, Burow ME, Wang G,  Proteomic analysis of tumor necrosis factor-α resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype, 2008,  Breast Cancer Research,  10(6):R105. Epub 2008 Dec 16.
13. Andrea L. Liebl, Lisa Granados, Qiang Zhang, Guangdi Wang, Howard W. Mielke, Christopher.R. Gonzalez, Don Ennis, Bernard B. Rees: Effects of post-hurricane Katrina New Orleans (LA, USA) sediments on early development of the Japanese Medaka (oryzias latipes). Environ. Chem. Toxicol., 2008, 27:2557-2564.
14. Guangdi Wang, Qiang Zhang, Peng Ma, Jordania Rowden, Howard W. Mielke, Chris Gonzales, and Eric Powell: Source and distribution of polycyclic aromatic hydrocarbons in urban soils: a case study of Detroit and New Orleans, 2008, Soil and Sediment Contamination, 17:1-17.
15. Abeer Alnafisi, Janet Hughes, Guangdi Wang and Charles A. Miller III: “Evaluating polycyclic aromatic hydrocarbons and environmental samples for human aryl hydrocarbon receptor activation using a yeast bioassay”, Environmental Chemistry and Toxicology, 2007, 26: 1333-1339.
16. Tien L. Huang, Cyrus J. Bacchi, Nageswara. R. Kode, Qiang Zhang, Guangdi Wang, Nigel Yartlet, Donna Rattendi, Indira Londono, Lakshman Mazumder, Jean Jacques Vanden Eynde, Annie Mayence, Isaac O. Donkor: Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug, Int J Antimicrob Agents, 2007, 30 :555-561.
17. Shaoyuan Zhang, Qiang Zhang, Shameka Darisaw, Odi Ehie, and Guangdi Wang: “Simultaneous Quantification of Polycyclic Aromatic Hydrocarbons (PAHs), Polychlorinated biphenyls (PCBs), and Pharmaceuticals and Personal Care Products (PPCPs) in Mississippi River Water, in New Orleans, Louisiana, USA”, Chemosphere, 2007, 66:1057-1069.
18. Qiang Zhang, Peng Ma, Richard B. Cole, Guangdi Wang: “In Vitro Metabolism of JWH-015, an Aminoalkylindole Agonist for the Peripheral Cannabinoid Receptor”, Anal Bioanal Chem, 2006, 386:1345-1355.
19. Richard G. Painter, Vincent G. Valentine, Qiang Zhang, Gisele Lombard, Connie Thompson, Anand Viswanathan, Nicholas A. Lanson, Jr., Guangdi Wang, and Guoshun Wang: CFTR Expression in Human Neutrophils and the Phagolysosomal Chlorination Defect in Cystic Fibrosis. Biochemistry, 2006, 45:10260-10269.
20. Qiang Zhang, Peng Ma, Weiqun Wang, Richard B. Cole, and Guangdi Wang “In Vitro Metabolism of Diarylpyrazoles, a Novel Group of Cannabinoid Receptor Ligands”, Drug Metabolism and Disposition, 2005, 33(4): 508-517.
21. Weiqun Wang, Yousheng Hua, Guangdi Wang, and Richard B. Cole: Characterization of rat liver microsomal and hepatocytal metabolites of brevetoxins by liquid chromatography-electrospray tandem mass spectrometry. Anal Bioanal Chem. 2005, 383(1):67-75.
22. Guangdi Wang, Howard Mielke, Van Quach, Chris Gonzales, and Qiang Zhang “Determination of Polycyclic Aromatic Hydrocarbons and Trace Metals in New Orleans Soils and Sediments”, Soil and Sediment Contamination, 2004, 13: 313-327.
23. Qiang Zhang, Peng Ma, Weiqun Wang, Richard B. Cole, and Guangdi Wang “Characterization of rat liver microsomal metabolites of AM-630, a potent cannabinoid receptor antagonist, by high performance liquid chromatography/electrospray ionization tandem mass spectrometry”, J. Mass Spectrom., 2004, 39:672-681.