DEPARTMENT OF CHEMISTRY
 

 
FACULTY/Staff PROFILE
seporator

Abha Verma, Ph.D.
Instructor

Telephone Number: 504-520-5408
Room Number: NCF - Room 301 L
Email Address: averma1@xula.edu
 

 

Courses

General Chemistry I Lab & General Chemistry II Lab

 

Short Professional Biography

Abha Verma received her B.Sc. (Honors) in Chemistry in 2002 and M.Sc. (Honors) in Chemistry in 2004 from Panjab University, Chandigarh (India) where she worked on novel synthesis of nor-capsaicin using microwave irradiations and usual conventional methods. She worked at Dr. Reddy's Pharmaceutical Company, Hyderabad in India for six months where she synthesized biological active molecules for different therapeutic areas. She joined Indian Institute of Science at Bangalore, India where she worked for a Chemical Biology program for two years for synthesis of moisture sensitive selenium based small molecules and got hands on experience of polyacrylamide gel-electrophoresis. In August 2007, she joined the chemistry graduate program at the University of New Orleans as a graduate assistant to pursue a PhD in organic chemistry and was a teaching assistant for 2 years for different class and laboratory courses. In December, of year 2007 she joined the research group of Prof. Mark L. Trudell at University of New Orleans, New Orleans and obtained a M.S. degree in 2010 for her work on synthesis of novel tropane compounds as potential therapeutics for drug abuse. She was then promoted as a research assistant to work towards her Ph.D. degree under supervision of Prof. Trudell at University of New Orleans, New Orleans. Her dissertation research primarily focused on synthesis of novel 1,2,3-triazole based compounds as cannabinoids antagonists for the treatment of drug abuse and become proficient in designing few steps schemes to synthesize new drug candidates and novel analogs based on rationale structure-based and structure-activity relationship based drug design. She also pursued synthesis of heterocyclic systems using Iridium catalysts. She has also organized and volunteered for several community outreach activities and student-socials to promote chemistry and attract students.

 

Research Interest

Dr. Watt's research activities focus on molecular recognition in biochemical systems.  He is currently researching how a small number of lysine deacetylases (KDACs, also known as histone deacetylases or HDACs) distinguish between the thousands of intracellular proteins that could serve as reaction substrates.  Acetylation of lysine is one of the most common post-translation modifications of proteins, and the acetylation/deacetylation cycle has central roles in gene expression, regulation of intracellular processes, and development of cancers.  To characterize KDAC substrate binding, Dr. Watt uses spectroscopy, high-throughput enzyme kinetics, molecular biology, statistical models, and molecular modeling.

 

Honors and Awards:
  • UNO Foundation Research Poster Competition, 1st Prize Graduate Division (2011-2012).
  • John C. Stowell Memorial Outstanding Teaching Assistant Award (2008).
  • Student Leadership Recognition award by University of New Orleans (2008-2009), (2009-2010) & (2010-2011).
  • Excelled in National Entrance Test conducted by University Grants Commission Government of India (2005).
  • Excelled in National level Graduate Aptitude Test in Engineering with 96 percentile (2005).
  • Financial Scholarship Award for graduates, awarded by Yogoda Satsang Society of India (2003).

 

Recent Publications
  • Cararas, Shaine A.; Izenwasser, Sari; Wade, Dean; Housman, Amy; Verma, Abha; Lomenzo, Stacey A.; Trudell, Mark L. Further structure–activity relationship studies on 8-substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo [3.2.1] octane derivatives at monoamine Transporters Bioorganic & Medicinal Chemistry 2011, 19 (24), 7551-7558.
  • Verma, Abha Sodium hydride Synlett 2010, 15, 2361-2362.
  • Kaur, Harneet; Izenwasser, Sari; Verma, Abha; Wade, Dean; Housman, Amy; Stevens, Edwin D.; Mobley, David L.; Trudell, Mark L. Synthesis and monoamine transporter affinity of 3α-arylmethoxy-3β-arylnortropanes Bioorganic & Medicinal Chemistry Letters 200919 (24), 6865-6868.
  • Verma, Abha; Stevens, Edwin D. N-(4-Hydroxyphenyl)-2-(1,1,3-trioxo-2,3-dihydro-1,2-benzothiazol-2-yl)acetamide Acta Crystallographica, Section E: Structure Reports Online 2009E65 (7), o1667.
  • Verma, Abha; Shu, Hong; Izenwasser, Sari; Gulasey, Gerard; Wade, Dean; Mobley, David L.; Fournet, Steven; Stevens, Edwin D.; Lomenzo, Stacey A.; Trudell, Mark L. Synthesis, Structure and CNS Cannabinoid Receptor Activity of 4-Alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles. Discovery of 1-(2,4-Dichlorophenyl)-5-(4-chlorophenyl)-4-propylcarbonyl-1H-1,2,3-triazole as a Potent CB1 Neutral Antagonist.Submitted to J. Med Chem. 2011.
  • Verma, Abha; Shu, Hong; Izenwasser, Sari; Gulasey, Gerard; Wade, Dean; Mobley, David L.; Fournet, Steven; Stevens, Edwin D.; Lomenzo, Stacey A.; Trudell, Mark L. Synthesis, Structure and CNS Cannabinoid Receptor Activity of 4-Alkanone-1,5-diaryl-1,2,3-triazoles. Discovery of 1-(2,4-Dichlorophenyl)-5-(4-chlorophenyl)-4-propylcarbonyl-1H-1,2,3-triazole as a Potent CB1 Neutral Antagonist. Manuscript in preparation.
  • Verma, Abha; Trudell, Mark L. Enantioselective Iridium catalyzed intramolecular N-heterocyclization of amino alcohols. Manuscript in preparation.
  • Verma, Abha Design, Synthesis and Biological Evaluation of novel cannabinoid antagonists Xavier Chemistry Club General Body Meeting, Xavier University, New Orleans, LA, USA, Feb 23, 2012.
  • Verma, Abha; Izenwasser, Sari; Wade, Dean; Booth, Caitlin; Trudell, Mark L.  Synthesis and Biological Evaluation of Novel Cannabinoid Antagonists 73rd Annual Scientific Meeting of the College on Problems of Drug Dependence, June 18-23, 2011. Abstract 65.
  • Kaur, Harneet; Izenwasser, Sari; Verma, Abha; Wade, Dean; Housman, Amy; Gulasey, Gerard; Trudell, Mark L. Synthesis and Monoamine Transporter Affinity of 3-Aryl-3-Arylmethoxytropane Derivatives 73rd Annual Scientific Meeting of the College on Problems of Drug Dependence, June 18-23, 2011. Abstract 64.
  • Izaguirre, Yiressy C.; Verma, Abha; Stevens, Edwin D.; Fournet, Steven; Trudell, Mark L. Synthesis and structure of novel acetaminophen derivatives Abstracts of Papers, 241st ACS National Meeting & Exposition, Anaheim, CA, United States, March 27-31, 2011. CHED-751.
  • Verma, Abha; Izenwasser, Sari; Trudell, Mark L. Synthesis and biological evaluation of novel cannabinoid antagonists Abstracts, Joint 66th Southwest and 62nd Southeast Regional Meeting of the American Chemical Society, New Orleans, LA, United States, December 1-4, 2010. SESW-794.
  • Izaguirre, Yiressy C.; Verma, Abha; Trudell, Mark L. Synthesis and structure of novel acetaminophen derivatives Abstracts, Joint 66th Southwest and 62nd Southeast Regional Meeting of the American Chemical Society, New Orleans, LA, United States, December 1-4, 2010. SESW-1072.
  • Verma, Abha; Izenwasser, Sari; Trudell, Mark L. Synthesis and biological evaluation of novel [1,2,3]triazoles at cannabinoid receptors Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010.  MEDI-211.

 

 

 
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