LOUISIANA CANCER RESEARCH CONSORTIUM AT XAVIER
 
 
 
Partha Bhattacharjee, Ph.D.
seporator
Partha Bhattacharjee
Office: 403B NCF
Phone: (504) 520-5269
pbhattac@xula.edu

Biographical Narrative

Dr. Partha S. Bhattacharjee is an Assistant Professor in the Department of Biology at Xavier University of Louisiana and an Adjunct Assistant Professor in the Department of Ophthalmology in Louisiana State University Health Sciences Center. Dr. Bhattacharjee has completed his PhD in Virology from University of Liverpool, England with a Commonwealth Scholarship from Association of Commonwealth Universities, UK. Upon completing his PhD, Dr. Bhattacharjee has performed postdoctoral fellowships at various universities, including College of Veterinary Medicine, Kansas State University and Department of Ophthalmology, Louisiana State University Health Sciences Center. During these postdoctoral fellowships, his primary focus was to explore the molecular aspects of herpes simplex virus type 1(HSV-1) latency and therapeutic intervention of ocular HSV-1 infection. In the year 2006, Dr. Bhattacharjee joined the faculty of Louisiana State University as a Research Assistant Professor in the Department of Ophthalmology. In 2008, Dr Bhattacharjee accepted Assistant Professorship in the Biology Department of Xavier University of Louisiana.

Research Overview

Dr. Bhattacharjee’s research focuses on developing a therapy against Herpes Simplex Virus Type I (HSV-1) infection and inflammation using novel peptides that mimic human apolipoprotein E (apoE).Genetic analyses have shown that an isoform of human apoE, apoE ε4, is found in significantly greater percentages in patients with inflammatory diseases such as Alzheimer’s, atherosclerosis, HIV and HSV-1 infections. Data obtained inDr. Bhattacharjee’s lab strongly suggest that an antiviral peptide derived from the heparan sulfate proteoglycans (HSPG) binding region of human apoE inhibits primary herpetic stromal keratitis (HSK). Specific goals of this lab are to test the therapeutic efficacy of antiviral HSPG binding region and macrophage receptor binding region derived peptides in the treatment of HSK.

Dr. Bhattacharjee is also interested in identifying the inflammatory cytokines and cells that are down regulated as a result of this treatment.

In addition to exploring the therapeutic efficacy of novel peptides in HSK treatment, Dr Bhattacharjee is also dedicated to developing treatment against angiogenesis. Angiogenesis is relevant not only to cancer but also to non-neoplastic diseases such as: macular degeneration, psoriasis, endometriosis, and arthritis. Hence it has been identified as a validated target for cancer treatment. Data obtained from Dr. Bhattacharjee’s lab demonstrated that a novel dimer peptide (apoEdp) derived from the receptor binding region of human apolipoprotein E (apoE) inhibits human umbilical vein endothelial cell proliferation, migration, invasion and capillary tube formation. Dr. Bhattacharjee’s lab has shown that apoEdp suppresses ocular angiogenesis and tumor progression.


Selected Publications

Year 2010
Clement, Christian; Bhattacharjee, Partha; Kumar, Manish; Foster, Timothy; Thompson, Hilary and Hill, James. Upregulation of mouse genes in HSV-1 latent TG after butyrate treatment implicates the multiple roles of the LAT-ICP0 locus. Invest Ophthalmol Vis Sci. In press.

David P. Kennedy, Christian Clement, Partha S. Bhattacharjee, Tashfin S. Huq, James M. Hill. Ocular HSV-1 DNA: Is the Cornea a Reservoir for Latency or a Fast Pit Stop?. Cornea. 2010. In press.

Clinical and Antiviral Efficacy of an Ophthalmic Formulation of Dexamethasone Povidone-Iodine in a Rabbit Model of Adenoviral Keratoconjunctivitis. Clement C, Capriotti JA, Kumar M, Hobden JA, Foster TP, Bhattacharjee PS, Thompson H, Mahmud R, Liang B, Hill JM. Invest Ophthalmol Vis Sci. 2010 Aug 11. PMID: 20702820

Acyclovir or Abeta42 peptides attenuate HSV-1-induced miRNA-146a levels in human primary brain cells. Lukiw WJ, Cui JG, Yuan LY, Bhattacharjee PS, Corkern M, Clement C, Kammerman EM, Ball MJ, Zhao Y, Sullivan PM, Hill JM. Neuroreport. 2010 Jul 29. PMID: 20683212

Effect of high versus low oral doses of valacyclovir on herpes simplex virus-1 DNA shedding into tears of latently infected rabbits. Kumar M, Kaufman HE, Clement C, Bhattacharjee PS, Huq TS, Varnell ED, Thompson H, Hill JM. Invest Ophthalmol Vis Sci. 2010 Apr 14. PMID: 20393107

Drug delivery to the posterior segment of the eye for pharmacologic therapy. Shah SS, Denham LV, Elison JR, Bhattacharjee PS, Clement C, Huq T, Hill JM. Expert Rev Ophthalmol. 2010 Feb 1;5(1):75-93. PMID: 20305803

Year 2009
1. Bhattacharjee PS, Neumann DM, Hill JM. A human apolipoprotein E mimetic peptide effectively inhibits HSV-1 TK-positive and TK-negative acute epithelial keratitis in rabbits. Curr Eye Res. 2009 Feb; 34(2):99-102. PMID: 19219680

2.  Clement C, Bhattacharjee PS, Kaufman HE, Hill JM. Heat-Induced Reactivation of HSV-1 in Latently Infected Mice: Upregulation in the Trigeminal Ganglia of Predominantly CD83 and Other Immune Response Genes and their Potential Role in the Viral LAT-ICP0 Locus. Invest Ophthalmol Vis Sci. 2009 Jan 17. PMID: 19151393

Year 2008
1.  Bhattacharjee PS, Neumann DM, Foster TP., Clement C., Singh G., Thompson H., Kaufman HE. and Hill JM. Effective Treatment of Ocular HSK with a Human Apolipoprotein E Mimetic Peptide in a Mouse Eye Model. Invest Ophthalmol Vis Sci. 2008. PMID: 18515564

2.  Bhattacharjee PS, Neumann DM, Foster TP., Bouhanik S., Clement C., Vinay D., Thompson H. and Hill JM. Effect of human apolipoprotein E genotype on the pathogenesis of experimental ocular HSV-1. Exp Eye Res. 2008,  PMID: 18572164.

3. Clement C, Popp MP, Bloom DC, Schultz G, Liu L, Neumann DM, Bhattacharjee PS and Hill JM. Microarray analysis of host gene expression for comparison between naïve and HSV-1 latent rabbit trigeminal ganglia. Molecular Vision Mol Vis. 2008 3;14:1209-21.PMID: 18615202

4. Toma HS, Murina AT, Areaux RG Jr, Neumann DM, Bhattacharjee PS, Foster TP, Kaufman HE, Hill JM. Ocular HSV-1 Latency, Reactivation and Recurrent Disease. Semin Ophthalmol. 2008 ;23(4):249-73. PMID: 18584563

5. Hill JM, Ball MJ, Neumann DM, Azcuy AM, Bhattacharjee PS, Bouhanik S, Clement C, Lukiw WJ, Foster TP, Kumar M, Kaufman HE, Thompson HW. The High Prevalence of HSV-1 DNA in Human Trigeminal Ganglia Is Not a Function of Age or Gender. J Virol. 2008.  PMID: 18550674

6.Giordani NV, Neumann DM, Kwiatkowski DL, Bhattacharjee PS, McAnany PK, Hill JM, Bloom DC. During herpes simplex virus type 1 infection of rabbits, the ability to express the latency-associated transcript increases latent-phase transcription of lytic genes. J Virol. 2008;82(12):6056-60. PMID: 18400860

Year 2007
1. Neumann DM, Bhattacharjee PS, Giordani N, Bloom DC, Hill JM.  In vivo changes in the patterns of chromatin structures associated with the HSV-1 genome in the latent mouse trigeminal ganglia can be detected at early times after butyrate treatment. J Virol 81(23):13248-53, 2007.  PMID:17881451

2. Neumann DM, Bhattacharjee PS, Hill, JM. Sodium butyrate: a chemical inducer of in vivo reactivation of HSV-1 in the ocular mouse model.  J Virol 81(11):6106-10, 2007.  PMID:17360760.

3. Hill JM, Bhattacharjee PS, Neumann DM.  Apolipoprotein E alleles can contribute to the pathogenesis of numerous clinical conditions including HSV-1 corneal disease.  Exp Eye Res 84(5):801-11, 2007.  PMID:17007837

Year 2006
1. Bhattacharjee PS, Neumann DM, Stark D, Thompson HW, Hill JM:  Apolipoprotein E modulates establishment             of HSV-1 latency and survival in a mouse ocular model.  Curr Eye Res 31(9):703-8, 2006.  PM16966142

Publications beyond 5 years

1. Hill JM, Patel A, Bhattacharjee PS, and Krause PR:  An HSV-1 chimeric containing HSV-2 latency-associated transcript (LAT) sequences has significantly reduced adrenergic reactivation in the rabbit eye model.  Curr Eye Res.  26(3-4):219-24, 2003.  PMID:12815550.

2. Miller CS, Bhattacharjee PS, Higaki S, Jacob RJ, Danaher RJ, Hill JM: Herpesvirus quiescence (QIF) in neuronal cells. VI: correlative analysis demonstrates usefulness of QIF-PC12 cells to examine HSV-1 latency and reactivation and deregulated LAT ORF expression.  Curr Eye Res 26(3-4)::239-48, 2003.  PMID: 12815553.

3. Marquart ME, Bhattacharjee PS, Zheng X, Kaufman HE, Thompson HW, Varnell ED, Hill JM: Ocular             reactivation phenotype of HSV-1 strain F(MPE)E, a corticosteroid-sensitive strain.  Curr Eye Res. 26(3-4):205-9, 2003.  PMID: 12815548

4. Anand BS, Hill JM, Dey S, Maruyama K, Bhattacharjee PS, Myles ME, Nashed YE, Mitra AK: In vivo antiviral efficacy of a dipeptide acyclovir prodrug, val-val-acyclovir, against HSV-1 epithelial and stromal keratitis in the rabbit eye model.  Invest Ophthalmol Vis Sci 44(6):2529-534, 2003.  PMID: 12766053

5. Bhattacharjee PS, Tran RK, Myles ME, Maruyama K, Mallakin A, Bloom DC, Hill JM: Overlapping sub deletions within a 348 bp region in the 5' exon of the LAT region that facilitates epinephrine-induced reactivation of HSV-1 in the rabbit ocular model do not further define a functional element.  Virology       312(1):151-58, 2003.  PMID: 12890628.

6. Chowdhury SI, Onderci M, Bhattacharjee PS, Al-Mubarak A, Weiss ML, Zhou Y: Bovine herpesvirus 5(BHV-5) Us9 is essential for BHV-5 neuropathogenesis. J Virol 76(8):3839-51, 2002.  PMID: 11907224

7. A.T.M.M-E-Elahi; S. Habib; M.S. Mazumder; M.I. Hossain; P.S. Bhattacharjee.  Comparison of Genetic Susceptibility Between Local and Exotic Chickens Towards Gumboro Disease. Pakistan Journal of Biological Sciences Year: 2001 Vol: 4 Issue: 12 Pages/record No.: 1562-1564

8. Bhattacharjee, P.S., Huq, H., Mazumder, J.M., Hossain, E. and Mia, A.H. (1998).Multiple drug resistnce of Pasteurella multocida organism isolated from buffaloes of Bangladesh.  Bangladesh Veterinary Journal. 32(1-2):67-69.

9. Bhattacharjee PS, Jones RC. (1997) Susceptibility of organ cultures from chicken tissues for strains of infectious bronchitis virus isolated from the intestine.  Avian Pathology, 26 (3): 553-563. PMID: 18483928

10. Bhattacharjee, PS; Savage, CE; Jones, RC. Tracheal cross-protection against enteric strains of infectious bronchitis virus by a conventional vaccine Indian Journal of Animal Sciences, 67 (3): 177-179 Mar. 1997

11. Bhattacharjee P.S., Kundu, R.L., Biswas, R.K., Mazumder, J.U., Hossain, E. and Miah, A.H. (1996) A retrospective analysis of chicken diseases diagnosed at the Central Disease Investigation Laboratory Dhaka. Bangladesh Veterinary Journal. 30 (3-4):105-113

12. Bhattacharjee, P.S., McArdle, F. and Jones, R.C. (1996). Differences observed between two strains of infectious bronchitis virus by Western blot analysis. Bangladesh Journal of Microbiology. 13 (1-2):1-3.

13. Bhattacharjee, P.S., Majumder, J.U., Miah, A.H., Ali, M.I. and Rahman, M.M. (1996). Prevalence of infectious bronchitis antibodies in chickens in Bangladesh. Bangladesh Veterinary Journal. 30(1-2):01-06.

14. Rahman, M.M., Rahman, M.M., Rahman, A., Islam, A.H.M.N., Miah, A.H., Majumder, J.U. and Bhattacharjee, P.S. (1996). Observations on outbreaks and subsequent control of infectious bursal disease in the central poultry farm in Bangladesh. 30 (1-2):13-17

15. Bhattacharjee, P.S. and Jones, R.C. (1996). Sensitivity of enteric strains of infectious bronchitis virus to bile salts, trypsin and amylase. Bangladesh Journal of Microbiology, 13: 1-2, 101-103.

16. Bhattacharjee PS, Carter SD, Savage CE, Jones RC. Re-excretion of infectious bronchitis virus in chickens induced by cyclosporin. Avian Pathol. 1995 Sep;24(3):435-41. PMID: 1864580

17.  Bhattacharjee PS, Naylor CJ, Jones RC. A simple method for immunofluorescence staining of tracheal organ cultures for the rapid identification of infectious bronchitis virus. Avian Pathol. 1994 Sep;23(3):471-80. PMID: 18671114

Research Grants

Ongoing Research Grants

NIH/NEI-1R21EY019144-01
Role: Principal Investigator $343,000
Title: A novel peptide therapy for treatment of herpetic stromal keratitis
10/01/2009 - 09/29/2011
Major Goals:
Herpetic stromal keratitis (HSK) is a chronic inflammatory disease of the eye caused by herpes simplex virus-1. Its recurrent nature and patients’ failure to respond to intensive antiviral and anti-inflammatory chemotherapeutics make this potentially blinding disease difficult to treat. We propose to investigate the effectiveness of two small peptides for their anti-viral and anti-inflammatory properties for the treatment of HSK.   

LCRC (Louisiana Cancer Research Consortium) grant. 
Role: Principal Investigator                                                                                                  $50,000
Title: “Novel peptide inhibitors of angiogenesis”.                                     8/19/08-6/30/2010
Major Goal: The major goal of this project is to develop selective heparanase inhibitors using the heparanase/HS-mimetic peptide complex by the method of rational drug design and to test whether these inhibitors possess selective inhibitory activity against heparanase in vitro and in vivo.

Center for Undergraduate Research [Xavier University of Louisiana]                            
Role: Principal Investigator                                                                                                  $10,000 Title: “A novel peptide inhibitor of angiogenesis”.                                     1/6/2010-8/31/10
Major Goal: Signaling pathway based therapeutic strategy against cancer is my focus of research. I would like to train my students in this relatively new area of research that may be beneficial in the future to the health care profession, especially in drug discovery. Students will gain about 90% hands-on experience.

Pending Research Grants

Completed Research Grants

MIE-STEM faculty grant from  Xavier University of Louisiana.
Role: Principal Investigator                                                                                                  $59,791
Title: “A novel peptide inhibitor of inflammatory angiogeneis”.                              8/19/08-7/30/2009
Major Goal: The major goal of our research project was to determine whether human apoE derived HS-mimetic peptides inhibit angiogenesis in mouse and rabbit corneal micropocket angiogenesis assay in vivo through downregulation of pro-inflammatory and pro-angiogenic cytokines.

Louisiana State University Health Sciences Center (LSUHSC) translational Research Award.
Role: Principal Investigator                                                                                                  $66,370
Title: “Therapy to Block Human Apolipoprotein-E4 (apoE4) mediated Herpes Keratitis (HSK)             and HSV-1 Neuroinvasiveness: A Mouse and Human Study”          1/2/2007-8/18/2008
Major Goal: The major goal of this proposal was to determine the therapeutic efficacy of two apoE mimetic anti-infective peptides against herpes virus infection of the eye. Our novel innovative approach with that proposal was focused on anti-infective roles of those two peptides in blocking herpes infections.

PATENTS

2010
Patent: Pending.
Patent application title: A novel peptide inhibitor of tumor angiogenesis
Principal Inventors: Partha S Bhattacharjee, Tarun K. Mandal, Tashfin Huq

 

2009
Patent: International patent filed on 10/2/2009. No. PCT/US2009/033672
Patent title: Peptide therapy for ocular herpes infections
Principal Inventors: James M Hill, Partha S. Bhattacharjee, Donna M Neumann

HONORS AND AWARDS

2009    National Institute of Health(NIH)-R21 Award
2009    Center for Undergraduate Research Award –Xavier University of Louisiana
2009    Louisiana Cancer Research Consortium (LCRC) Award
2008    MIE- Faculty start up-Grants, Xavier Univ. of Louisiana
2007    Received LSUHSC translational Research Initiative award designated as Chancellor’s award.
1999    Senior Research Fellowship (Bangladesh) from Ministry of Science and Technology to perform contract research on Birna virus.
1996    Senior Research Fellowship (Bangladesh) from Ministry of Science and Technology to perform contract research of corona virus.
1995    University (Bangladesh Agricultural University) Prize for securing First Class First position in DVM
1990    Scholarship from Association of Commonwealth Universities by British Government tenable at UK to do PhD
1986    National Science and Technology fellowship (Bangladesh) to obtain M.Sc. in Veterinary Science from Ministry of Science and Technology.
1983    University Grants Commission (UGC, Bangladesh) merit award in Undergraduate Veterinary Studies.

AFFILIATIONS

American Society for Virology (ASV)

The Association of Research in Vision and Ophthalmology (ARVO)

Louisiana Cancer Research Consortium(LCRC)

American Society for Microbiology (ASM)

 
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