LOUISIANA CANCER RESEARCH CONSORTIUM AT XAVIER
 
 
 
Thomas Wiese, Ph.D.
seporator

Thomas Wiese, Ph.D.
Xavier Associate Director
Associate Professor
College of Pharmacy
twiese@xula.edu
520-7433

Thomas Wiese, Ph.D. is an associate professor in the Department of Basic Pharmaceutical Sciences. Dr. Wiese is the Xavier Associate Director of the LCRC. His office is located in room 309 COP.

Publications

1. Wiese, T.E., Kral, L.G., Dennis, K.E., Butler, W.B., Brooks, S.C. (1992) Optimization of estrogen growth response in MCF-7 cells. In Vitro Cellular & Developmental Biology 28A:9-10, pp 595-602

2.    VanderKuur, J.A., Wiese, T., Brooks, S.C. (1993) Influence of estrogen structure on nuclear binding and progesterone receptor induction by the receptor complex. Biochemistry 32:27, pp 7002-7008

3.    Horwitz, J.P., Massova, I., Wiese, T.E., Wozniak, A.J., Corbett, T.H., Sebolt-Leopold, J.S., Capps, D.B., Leopold, W.R. (1993) Comparative molecular field analysis of in vitro growth inhibition of L1210 and HCT-8 cells by some pyrazoloacridines. J  Med Chem 36:23, pp 3511-6

4.    Horwitz, J.P., Massova, I., Wiese, T.E., Besler, B.H., Corbett, T.H. (1994) Comparative molecular field analysis of the antitumor activity of 9H-thioxanthen-9-one derivatives against pancreatic ductal carcinoma 03 [published erratum appears in J Med Chem 1994 Sep 16;37(19):3196]. J Med Chem 37:6, pp 781-6

5.    Wiese, T.E., Brooks, S.C. (1994) Molecular modeling of steroidal estrogens:  Novel conformations and their role in biological activity. J Steroid Biochem Mol Biol 50:1-2, pp 61-73

6.    Wiese, T.E., Dukes, D., Brooks, S.C. (1995) A molecular modeling analysis of diethylstilbestrol conformations and their similarity to estradiol-17beta. Steroids 60:12, pp 802-808

7.    Waller, C.L., Oprea, T.I., Chae, K., Park, H.-K., Korach, K.S., Laws, S.C., Wiese, T.E., Kelce, W.R., Gray, L.E. (1996) Ligand-based identification of environmental estrogens. Chem Res Toxicol 9, pp 1240-1248

8.    Gray, L.E., Kelce, W.R., Wiese, T., Tyl, R., Gaido, K., Cook, J., Klinefelter, G., Desaulniers, D., Wilson, E., Zacharewski, T., Waller, C., Foster, P., Laskey, J., Reel, J., Giesy, J., Laws, S., McLachlan, J., Breslin, W., Cooper, R., Di Giulio, R., Johnson, R., Purdy, R., Mihaich, E., Safe, S., Sonnenschein, C., Welshons, W., Miller, R., McMaster, S., Colborn, T. (1997) Endocrine screening methods workshop report: Detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms. Reprod Toxicol 11:5, pp 719-750

9.    Wiese, T.E., Polin, L.A., Palomino, E., Brooks, S.C. (1997) Induction of the estrogen specific mitogenic response of MCF-7 cells by selected analogues of estradiol-17ß: A 3D QSAR study. J Med Chem 40:22, pp 3659-3669

10.    Bolger, R., Nestich, S., Wiese, T., Ervin, K., Checovich, W. (1998) Rapid screening of environmental chemicals for estrogen receptor binding capacity. Environ Health Perspect 106:9, pp 551-557

11.    Walker, C., Ahmed, S.A., Brown, T., Ho, S.M., Hodges, L., Lucier, G., Russo, J., Weigel, N., Weise, T., Vandenbergh, J. (1999) Species, interindividual, and tissue specificity in endocrine signaling. Environmental Health Perspectives 107, pp 619-624

12.    Burow, M.E., Boue, S.M., Collins-Burow, B.M., Melnik, L.I., Duong, B.N., Carter-Wientjes, C.H., Li, S.F., Wiese, T.E., Cleveland, T.E., McLachlan, J.A. (2001) Phytochemical glyceollins, isolated from soy, mediate antihormonal effects through estrogen receptor alpha and beta. J Clin Endo Metab 86:4, pp 1750-1758

13.    Rubin, V.N., Ruenitz, P.C., Boyd, J.F., Boudinot, D., Wiese, T.E. (2002) Characterization of SERM activity in two triairylethylene oxybutyric acids. Biochemical Pharmacology 63, pp 1517-1525

14.    Coleman, K.P., Toscano, W.A., Wiese, T.E. (2003) QSAR Models of the in vitro Estrogen Activity of Bisphenol A Analogs. Quantitative Structure-Activity Relationships 22, pp 78-88

15.    Boue, S.M., Wiese, T.E., Nehls, S., Burow, M.E., Elliott, S., Carter-Wientjes, C.H., Shih, B.Y., McLachlan, J.A., Cleveland, T.E. (2003) Evaluation of the estrogenic effects of legume extracts containing phytoestrogens. Journal of Agricultural & Food Chemistry 51:8, pp 2193-9

18.    Boué SM, Tilghman SL, Elliot S, Zimmerman C, Williams K, Payton-Stewart F, Miraflor A, Carter-Wientjes CH, Shih BY, Wiese T, Cleveland E, McLachlan J, Burow ME (In Press) Identification of the potent phytoestrogen glycinol in elicited soybean (Glycine max). Endocrinology

19.    Zhou C, Nitschke AM, Xiong W, Zhang Q, Tang Y, Bloch M, Elliott S, Zhu Y, Bazzone L, Yu D, Weldon CB, Schiff R, McLachlan JA, Beckman BS, Wiese TE, Nephew KP, Shan B, Burow ME, Wang G (In Press) Proteomic analysis of tumor necrosis factor-α resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype. Breast Cancer Research

Current Support

Active
59-6435-2-0021      (T. Wiese sub-Project PI)           
10/1/03 – 4/30/10            10%
USDA                                    $170,000            “Defining the Hormone Activity of Plant Extracts and Dietary Supplements”, component of a USDA cooperative agreement with the Tulane-Xavier CBR.  This project examines the hormone activity of dietary supplements used to treat post-menopausal symptoms.

PO 434628            (PI: Wiese)                        6/1/04 – 9/30/10            10%
Shaw Environmental Inc.                        $175,160
“Estrogen and Androgen Activity Determinations of Water Samples using the MVLN and MDA-kb2 Assays”
This contract involves using reporter gene assays in stably transfected cells to evaluate the estrogen and androgen activity of hormones in extracts of water samples that have been treated by various remediation techniques in ongoing studies at the US EPA in Cincinnati, OH.

P20 CA118767-01            (PI: Kennedy, Manager: Wiese)           
9/30/05 – 8/31/10                        10%
NIH NCI                                                $835,095
“Planning Grant Minority Institution/Cancer Center Collaboration”
This grant establishes a comprehensive planning process to develop collaborative initiatives in Cancer Education and Cancer Research with the Tulane Cancer Center that will lead to future self sustaining, collaborative programs at Xavier that address Health Disparities and Cancer.’   Currently in no cost extension year.

1G12RR026250-01 8/1/2009 – 7/31/2014
NIH-NCRR
Xavier’s RCMI Cancer Research Program
The goals of Xavier’s RCMI program are to enhance university-wide cancer research infrastructure and faculty research competitiveness by establishing core laboratories and supporting pilot projects.
Role: Core Leader

 

 
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