LOUISIANA CANCER RESEARCH CONSORTIUM AT XAVIER
 
 
 
Guangdi Wang, Ph.D.
seporator


Guangdi Wang, Ph.D.
Professor of Chemistry
Telephone Number: 504-520-5076
Room Number: NCF Annex - Room 339
Email Address: gwang@xula.edu
website: http://www.xula.edu/chemistry/profiles/gwang.php

Biographical Narrative

Dr. Guangdi Wang is Professor of Chemistry in the Department of Chemistry, Xavier University of Louisiana. He also holds adjunct faculty positions at Tulane University and the University of New Orleans where he collaborates with Professors John McLachlan, Matthew Burow, and Richard Cole on research involving proteomic analyses of breast cancer cells and fibroid cells. Dr. Wang holds a Ph.D. in Analytical Chemistry from the University of New Orleans. His graduate research focused on the fundamental aspects of mass spectrometry, which gave him extensive experience in sophisticated mass spectrometric techniques and their biomedical applications.

Research Interest

Dr. Guangdi Wang’s research focuses on: 1. Environmental studies that track the pollution levels of endocrine disruptors and carcinogens. 2. Study of breast cancer signaling pathways by proteomics analysis. 3. Design, synthesis, and biological evaluation of selective estrogen receptor modulators that can be used to treat breast cancer.

Publications

1. Zhou C, Xiong W, Zhang Q, Tang Y, Bloch M, Weldon CB, Elliott S, McLachlan JA, Barbara S. Beckman BS, Wiese TE, Burow ME, Wang G, Proteomic analysis of tumor necrosis factor-α resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype, 2008, Breast Cancer Research, 10(6):R105. Epub 2008 Dec 16.
2. Andrea L. Liebl, Lisa Granados, Qiang Zhang, Guangdi Wang, Howard W. Mielke, Christopher.R. Gonzalez, Don Ennis, Bernard B. Rees: Effects of post-hurricane Katrina New Orleans (LA, USA) sediments on early development of the Japanese Medaka (oryzias latipes). Environ. Chem. Toxicol., 2008, 27:2557-2564.
3. Guangdi Wang, Qiang Zhang, Peng Ma, Jordania Rowden, Howard W. Mielke, Chris Gonzales, and Eric Powell: Source and distribution of polycyclic aromatic hydrocarbons in urban soils: a case study of Detroit and New Orleans, 2008, Soil and Sediment Contamination, 17:1-17.
4. Abeer Alnafisi, Janet Hughes, Guangdi Wang and Charles A. Miller III: “Evaluating polycyclic aromatic hydrocarbons and environmental samples for human aryl hydrocarbon receptor activation using a yeast bioassay”, Environmental Chemistry and Toxicology, 2007, 26: 1333-1339.
5. Tien L. Huang, Cyrus J. Bacchi, Nageswara. R. Kode, Qiang Zhang, Guangdi Wang, Nigel Yartlet, Donna Rattendi, Indira Londono, Lakshman Mazumder, Jean Jacques Vanden Eynde, Annie Mayence, Isaac O. Donkor: Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug, Int J Antimicrob Agents, 2007, 30 :555-561.
6. Shaoyuan Zhang, Qiang Zhang, Shameka Darisaw, Odi Ehie, and Guangdi Wang: “Simultaneous Quantification of Polycyclic Aromatic Hydrocarbons (PAHs), Polychlorinated biphenyls (PCBs), and Pharmaceuticals and Personal Care Products (PPCPs) in Mississippi River Water, in New Orleans, Louisiana, USA”, Chemosphere, 2007, 66:1057-1069.
7. Qiang Zhang, Peng Ma, Richard B. Cole, Guangdi Wang: “In Vitro Metabolism of JWH-015, an Aminoalkylindole Agonist for the Peripheral Cannabinoid Receptor”, Anal Bioanal Chem, 2006, 386:1345-1355.
8. Richard G. Painter, Vincent G. Valentine, Qiang Zhang, Gisele Lombard, Connie Thompson, Anand Viswanathan, Nicholas A. Lanson, Jr., Guangdi Wang, and Guoshun Wang: CFTR Expression in Human Neutrophils and the Phagolysosomal Chlorination Defect in Cystic Fibrosis. Biochemistry, 2006, 45:10260-10269.
9. Qiang Zhang, Peng Ma, Weiqun Wang, Richard B. Cole, and Guangdi Wang “In Vitro Metabolism of Diarylpyrazoles, a Novel Group of Cannabinoid Receptor Ligands”, Drug Metabolism and Disposition, 2005, 33(4): 508-517.
10. Weiqun Wang, Yousheng Hua, Guangdi Wang, and Richard B. Cole: Characterization of rat liver microsomal and hepatocytal metabolites of brevetoxins by liquid chromatography-electrospray tandem mass spectrometry. Anal Bioanal Chem. 2005, 383(1):67-75.
11. Guangdi Wang, Howard Mielke, Van Quach, Chris Gonzales, and Qiang Zhang “Determination of Polycyclic Aromatic Hydrocarbons and Trace Metals in New Orleans Soils and Sediments”, Soil and Sediment Contamination, 2004, 13: 313-327.
12. Qiang Zhang, Peng Ma, Weiqun Wang, Richard B. Cole, and Guangdi Wang “Characterization of rat liver microsomal metabolites of AM-630, a potent cannabinoid receptor antagonist, by high performance liquid chromatography/electrospray ionization tandem mass spectrometry”, J. Mass Spectrom., 2004, 39:672-681.
13. Mielke, Howard W., Wang, Guangdi, Gonzales, Christopher R., Powell, Eric T., Zhang, Qiang and Quach, V. Nancy, “PAHs and Metals in Soils of Inner City and Suburban New Orleans, Louisiana USA”, Environmental Toxicology and Pharmacology, 2004, 18:243-247.

Current Funding

W81XWH-04-1-0557 DOD 04/19/2004-4/18/2010)
“Chemoresistance in Breast Carcinoma Cells: MEK5-BMK/Erk5 Expression and Proteomic Analyses”
The goal of the proposed research is to elucidate the specific mechanisms by which the MEK5 signaling pathways mediate progression to a drug-resistant phenotype in breast carcinoma cells.
Role: PI

N00014-06-1-1136 10/1/2006 – 9/30/2010
Office of Naval Research
“Contaminant Profiling of Marine/Estuary Sediments”
The goal of this project is to characterize the contaminant profile of marine sediments in the Gulf of Mexico by collecting and analyzing sediment samples for contamination by four major groups of POPs including 17 PAHs, 28 PCBs, 29 organochlorines, and 12 pharmaceutically active compounds.
Role: PI

59-6435-8-317 7/1/2008 – 6/30/2013
USDA
Design and Synthesis of Isoflavone and Glyceollin Derivatives as Potential Antagonists for the Estrogen Receptor
The goal of the proposed research is to design, synthesize, and evaluate biological activities of various phytoestrogen analogues. The long term goal is to find potent estrogen receptor antagonists that have anti-estrogen and anti-proliferation properties against breast cancer.
Role: PI

1G12RR026250-01 8/1/2009 – 7/31/2014
NIH-NCRR
Xavier’s RCMI Cancer Research Program
The goals of Xavier’s RCMI program are to enhance university-wide cancer research infrastructure and faculty research competitiveness by establishing core laboratories and supporting pilot projects.
Role: Program Director

 
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