Louisiana Cancer Research Consortium

Maryam Foroozesh, Ph.D.

Maryam Foroozesh, Ph.D.
Position Title: Times-Picayune/Samuel Newhouse Foundation Endowed Professor in Scientific Research
Office location: NCF Annex 335
Office phone: 504-520-5078
Email address: mforooze@xula.edu

Research Overview:
Dr. Foroozesh'Äôs research group is involved in the design, synthesis and biological studies of new selective inhibitors of P450 enzymes involved in carcinogenesis, and ceramides with the potential of causing reversal of chemoresistance and endocrine resistance in breast cancer.

Selected Peer-Reviewed Publications since 2000 (undergraduate student authors are underlined)
'ÄúInhibition of Cytochrome P450 6D1 by Alkynylarenes, Methylenedioxy Substituted Aromatics and other Aromatics'Äù, J.G. Scott, M. Foroozesh, N.E. Hopkins, and W.L. Alworth, Pesticide Biochemistry and Physiology, Vol. 67, pp. 63-71, 2000.

'Äú1-Adamantyl Propargyl Ether'Äù, J.T. Mague, W.L. Alworth, and M. Foroozesh, Acta Cryst., E57: 220-221, 2001.

'ÄúSynthesis of a Family of Adamantyl Propargyl Ethers as Potential Cytochrome P450 Inhibitors'Äù, A. Robinson, J. Mesbah, T. Smith, and M. Foroozesh, J. Undergraduate Chemistry Research, Vol. 4, pp. 155-157, 2002.

'ÄúMetabolic Fate of the AH Receptor Ligand 6-Formylindolo[3,2-b]carbazole'Äù, L. Bergander, A. Rannug, E. Wincent, M. Foroozesh, W. Alworth, and U. Rannug, Chem. Biol. Interact., 149: 151-64, 2004.

'ÄúSynthesis of a Family of Naphthyl Propargyl Ethers as Potential Cytochrome P450 Inhibitors'Äù, A.T. Kelley, J.Y. Mesbah, M.E. McKendall, T.P. Smith, and M. Foroozesh, J. Undergraduate Chemistry Research, Vol. 3, pp. 103-105, 2004.

'ÄúSynthesis of a Family of Biphenylpropargyl Ethers as Potential Inhibitors of P450 Enzymes. X-Ray Crystal Structure of 2,2'Äô-Biphenyldipropargyl Ether'Äù, B. Bowman, D. Lightsey, M. McKendall, T. Smith, N. Zhu, C. L. Klein Stevens, and M. Foroozesh, J. Undergraduate Chemistry Research, Vol. 2, pp. 57-61, 2005.

'ÄúNaphthoflavone Propargyl Ether Inhibitors of Cytochrome P450'Äù, N. Zhu, D. Lightsey, M. Foroozesh, W. Alworth, A. Chaudhary, K. L. Willet, and C.K. Stevens, J. Chemical Crystallography, Vol. 36, No. 5, pp. 289-295, 2006.

'ÄúMethoxyflavone Inhibitors of Cytochrome P450'Äù, M. McKendall, T. Smith, K. Ahn, J. Ellis, T. McGee, M. Foroozesh, N. Zhu, and C.L. Klein Stevens, Journal of Chemical Crystallography, Vol. 38, No. 4, pp. 231-237, 2008.

'ÄúDifferential Inhibition of P450s 3A4 and 3A5 By the Newly Synthesized Coumarin Derivatives, 7-Coumarin Propargyl Ether and 7-(4-Trifluoromethyl)coumarin Propargyl Ether'Äù, C. Sridar, U.M. Kent, A. McCall, W.L. Alworth, M. Foroozesh, and P. Hollenberg, Drug Metabolism and Disposition, Vol. 36, pp. 2234-2243, 2008.

'ÄúInteraction of Polycyclic Aromatic Hydrocarbons with Human Cytochrome P450 1B1 in Inhibiting Catalytic Activity'Äù, T. Shimada, N. Murayama, K. Tanaka, S. Takenaka, Y. Imai, N.E. Hopkins, M.K. Foroozesh, W.L. Alworth, H. Yamazaki, F.P. Guengerich, and M. Komori, Chemical Research in Toxicology, Vol. 21, No.12, pp. 2313-2323, 2008.

'ÄúReverse Type I Binding Spectra of Human Cytochrome P450 1B1 Induced by Flavonoid, Stilbene, Pyrene, Naphthalene, Phenanthrene, and Biphenyl Derivatives that Inhibit Catalytic Activity: A Structure-Function Relationship Study'Äù, T. Shimada, K. Tanaka, S. Takenaka, M.K. Foroozesh, N. Murayama, H. Yamazaki, F.P. Guengerich, and M. Komori, Chemical Research in Toxicology, Vol. 22, No. 7, pp. 1325-1333, 2009.

'ÄúDesign, Synthesis, and Biological Activity of a Family of Novel Ceramide Analogs in Chemoresistant Breast Cancer Cells'Äù, J.W. Antoon, J. Liu, M.M. Gestaut, M.E. Burow, B.S. Beckman, and M. Foroozesh, Journal of Medicinal Chemistry, Vol.52, No. 18, pp. 5748'Äì5752, 2009.

'ÄúEthynyl and Propynyl Pyrene Inhibitors of Cytochrome P450'Äù, N. Zhu, D. Lightsey, J. Liu, M. Foroozesh, K.M. Morgan, E. D. Stevens, and C.L.K. Stevens, Journal of Chemical Crystallography, Vol. 40, pp. 343-352, 2010.

'ÄúIn Silico Studies to Determine Structural Features Influencing Polyaromatic Hydrocarbon Inhibition Potency of Cytochrome P450 enzymes 1A1, 1A2, 2A6 and 2B1'Äù, J. Sridhar, P. Jin, J. Liu, M. Foroozesh, and C. Stevens, Chemical Research in Toxicology, Vol. 23, No. 3, pp. 600'Äì607, 2010.

'ÄúNovel D-erythro N-Octanoyl Sphingosine Analogues As Chemo- and Endocrine Resistant Breast Cancer Therapeutics'Äù, J. Antoon, J. Liu, A. Ponnapakkam, M. Foroozesh, and B. Beckman, Cancer Chemotherapy and Pharmacology, Vol. 65, No. 6, pp. 1191-1195, 2010.

'ÄúNovel Anti-Proliferative Ceramide Analogs: Design, Synthesis, and Structure-Activity Relationship Studies of Substituted (S)-2-(Benzylideneamino)-3-hydroxy-N-tetradecylpropanamides'Äù, J. Liu, J.W. Antoon, A. Ponnapakkam, B.S. Beckman, and Maryam Foroozesh, accepted for publication in Bioorganic and Medicinal Chemistry, May 2010.

Current Funding:
Foroozesh (PI) 01/01/2010-07/31/2010
NIH/The Research Centers in Minority Institutions (RCMI) Program, SEED Grant
Potential Reversal of Chemoresistance in Leukemia Cells Using Ceramide Derivatives
Role: PI

Louisiana Cancer Research Consortium

504-520-7433

twiese@xula.edu